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An automated chemistry module for the (18F)FDG production Wu, Jason Shao-Chun
Abstract
This thesis presents the design, chemical procedures, operation, optimization, and performance of a [¹⁸F]FDG synthesis module. Together with the EBCO/ TRIUMF TR 14 cyclotron in C.H.U.S., this module forms an integrated a [¹⁸F]FDG production line, employing aqueous [18F]fluoride as precursors and nucleophilic reaction as the fluorination step. 18 Among many short-lived positron emitting radionuclides, ¹⁸F is the most important and widely used nuclide due to its convenient half-life (t[sub ½] = 109 minutes). The emergence of a [¹⁸F]FDG as the most popular PET radiopharmaceutical has necessitated the development of routine methods of its production in the PET radiochemistry clinic. A synthesis module is required to produce large quantities of a [¹⁸F]FDG reliably, efficiently, and economically. In order to achieve this goal, the fluid transfer system, the heating/cooling mechanism, and the automated control of the module are the key design components. A modified chemistry module based on an EBCO/ TRIUMF design is constructed. After extensive cold tests, 40 hot tests are conducted in C.H.U.S. to optimize the module. Proper cleaning and operation procedures are developed and the optimum reaction parameters are established. The results are satisfactory, while the consistency in the yields displays a great reliability.
Item Metadata
Title |
An automated chemistry module for the (18F)FDG production
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Creator | |
Publisher |
University of British Columbia
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Date Issued |
2002
|
Description |
This thesis presents the design, chemical procedures, operation, optimization, and
performance of a [¹⁸F]FDG synthesis module. Together with the EBCO/ TRIUMF TR 14
cyclotron in C.H.U.S., this module forms an integrated a [¹⁸F]FDG production line,
employing aqueous [18F]fluoride as precursors and nucleophilic reaction as the
fluorination step.
18
Among many short-lived positron emitting radionuclides, ¹⁸F is the most
important and widely used nuclide due to its convenient half-life (t[sub ½] = 109 minutes).
The emergence of a [¹⁸F]FDG as the most popular PET radiopharmaceutical has
necessitated the development of routine methods of its production in the PET
radiochemistry clinic. A synthesis module is required to produce large quantities of
a [¹⁸F]FDG reliably, efficiently, and economically. In order to achieve this goal, the fluid
transfer system, the heating/cooling mechanism, and the automated control of the module
are the key design components.
A modified chemistry module based on an EBCO/ TRIUMF design is
constructed. After extensive cold tests, 40 hot tests are conducted in C.H.U.S. to
optimize the module. Proper cleaning and operation procedures are developed and the
optimum reaction parameters are established. The results are satisfactory, while the
consistency in the yields displays a great reliability.
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Extent |
5387710 bytes
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Genre | |
Type | |
File Format |
application/pdf
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Language |
eng
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Date Available |
2009-08-17
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Provider |
Vancouver : University of British Columbia Library
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Rights |
For non-commercial purposes only, such as research, private study and education. Additional conditions apply, see Terms of Use https://open.library.ubc.ca/terms_of_use.
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DOI |
10.14288/1.0085130
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URI | |
Degree | |
Program | |
Affiliation | |
Degree Grantor |
University of British Columbia
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Graduation Date |
2002-05
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Campus | |
Scholarly Level |
Graduate
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Aggregated Source Repository |
DSpace
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Rights
For non-commercial purposes only, such as research, private study and education. Additional conditions apply, see Terms of Use https://open.library.ubc.ca/terms_of_use.