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An investigation on the use of micro-ultrasonic-transducers for anticancer drugs cytotoxicity enhancement Siu, Tung

Abstract

Prototype ultrasonic transducers with resonance frequencies at 4 and lMHz were constructed using lead zirconate titanate (PZT) ceramics. Their output ultrasonic powers were measured using an electronic ultrasound power meter. The power coefficients of the 4 and 1 MHz transducers were found to be 1.98 and 1.85 respectively, close to the theoretical value of 2. The theoretical transmitted ultrasonic power through a polystyrene plate was 88% whereas the experimental values were 86% for lMHz and 71 % for 4MHz ultrasound. Overall, the measured characteristics of the selected transducers were in good agreement with theoretical values. The output ultrasonic powers were also found to be consistent over four months. Tone-burst ultrasound (32 Watt/cm2, 20% Duty Cycle, 50msec burst period) was found to significantly (p

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