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Effective exercise modality for postmenopausal women with type 2 diabetes Cuff, Darcye J.


The purpose of this study was to evaluate changes in insulin sensitivity assessed by hyperinsulinemic-euglycemic clamp after 16 weeks of aerobic plus resistance training (Ae + RT), aerobic only training (Ae only), or usual care in a group of 28 randomly assigned postmenopausal women with type 2 diabetes (T2D). A second purpose was to relate improvements in insulin sensitivity to changes in abdominal subcutaneous and visceral AT (AT) cross-sectional area and thigh muscle cross-sectional area and density as assessed by single-image computed tomography (CT) scans. Glucose disposal during the hyperinsulinemic-euglycemic clamp was significantly increased by 77% after Ae + RT training (pre 2.36 ± 0.33, post 4.17 + 0.65 mg/kg/min, p=0.007), with no significant change seen in either the usual care group (pre 2.29 ± 0.46, post 2.36 + 0.46 mg/kg/min) or the Ae only group (pre 2.78 + 0.49, post 3.33 ± 0.64 mg/kg/min). The Ae + RT group demonstrated significant losses of 10.5% from the visceral AT area (pre 251.1 ± 22.9 cm², post 224.8 ± 20.0 cm², p

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