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Endothelin-1 and oxygen saturation during exercise in normoxia and hyposia Giles, Luisa
Abstract
We tested the hypothesis that decrements in arterial oxyhaemoglobin saturation could be related to elevations in circulating endothelin-1 following 30 minutes of exercise at ventilatory threshold. Eight aerobically trained males (mean ± SEM: age 26.14 ± 1.77 years, height 182.36 ± 1 . 5 1 cm, mass 72.89 ± 2.62 kg) completed 2 maximal exercise tests (mean ± SEM: normoxia (n) 68.56 ± 2.06 mL.kg-¹min-¹; hypoxia (Fi02 0.14)(h) 53.88 ± 1.35 mL.kg-¹.min-¹), and two 30-minute steady state exercise protocols at the power achieved at threshold during maximal exercise tests (mean ± SEM: power (Watts) 257.14 ± 21.57 (n) 191.25 ± 10.79 (Fi02 0.14)(h); HR (bpm) 161.7 ± 5.34 (n) 156.6 ± 3.45 (h)). When participants exercised for 30 minutes at ventilatory threshold inspiring 14%02, a significant decrease in oxygen saturation (as measured by pulse oximetry) was observed, when compared to values in normoxia (80.2 ± 1.17 % (h) vs 94.12 ± 0.24 % (n); p<0.001). This desaturation was not accompanied by significant changes in plasma endothelin-1 (ET-1), big endothelin-1 (BigET-1) or nitric oxide (NO). Both pulmonary artery pressure (PAP) and oscillatory compliance (OC) were significantly greater following exercise (F[superscript omitted] = 4.74 p< 0.05), compared to pre-exercise values. These outcome variables were not different between normoxia and hypoxia. Plasma ET-1 or BigET-1 levels did not differ significantly over time or across conditions F[superscript omitted] = 4.74 p> 0.05). In conclusion, plasma ET-1 levels following 30-minutes of steady state exercise at ventilatory threshold are unrelated to decrements in oxyhaemoglobin saturation.
Item Metadata
Title |
Endothelin-1 and oxygen saturation during exercise in normoxia and hyposia
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Creator | |
Publisher |
University of British Columbia
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Date Issued |
2007
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Description |
We tested the hypothesis that decrements in arterial oxyhaemoglobin saturation
could be related to elevations in circulating endothelin-1 following 30 minutes of exercise
at ventilatory threshold. Eight aerobically trained males (mean ± SEM: age 26.14 ± 1.77
years, height 182.36 ± 1 . 5 1 cm, mass 72.89 ± 2.62 kg) completed 2 maximal exercise
tests (mean ± SEM: normoxia (n) 68.56 ± 2.06 mL.kg-¹min-¹; hypoxia (Fi02 0.14)(h)
53.88 ± 1.35 mL.kg-¹.min-¹), and two 30-minute steady state exercise protocols at the
power achieved at threshold during maximal exercise tests (mean ± SEM: power (Watts)
257.14 ± 21.57 (n) 191.25 ± 10.79 (Fi02 0.14)(h); HR (bpm) 161.7 ± 5.34 (n) 156.6 ±
3.45 (h)). When participants exercised for 30 minutes at ventilatory threshold inspiring
14%02, a significant decrease in oxygen saturation (as measured by pulse oximetry) was
observed, when compared to values in normoxia (80.2 ± 1.17 % (h) vs 94.12 ± 0.24 %
(n); p<0.001). This desaturation was not accompanied by significant changes in plasma
endothelin-1 (ET-1), big endothelin-1 (BigET-1) or nitric oxide (NO). Both pulmonary
artery pressure (PAP) and oscillatory compliance (OC) were significantly greater
following exercise (F[superscript omitted] = 4.74 p< 0.05), compared to pre-exercise values. These
outcome variables were not different between normoxia and hypoxia. Plasma ET-1 or
BigET-1 levels did not differ significantly over time or across conditions F[superscript omitted] = 4.74 p>
0.05).
In conclusion, plasma ET-1 levels following 30-minutes of steady state exercise at
ventilatory threshold are unrelated to decrements in oxyhaemoglobin saturation.
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Genre | |
Type | |
Language |
eng
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Date Available |
2011-03-21
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Provider |
Vancouver : University of British Columbia Library
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Rights |
For non-commercial purposes only, such as research, private study and education. Additional conditions apply, see Terms of Use https://open.library.ubc.ca/terms_of_use.
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DOI |
10.14288/1.0077010
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URI | |
Degree | |
Program | |
Affiliation | |
Degree Grantor |
University of British Columbia
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Campus | |
Scholarly Level |
Graduate
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Aggregated Source Repository |
DSpace
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Rights
For non-commercial purposes only, such as research, private study and education. Additional conditions apply, see Terms of Use https://open.library.ubc.ca/terms_of_use.