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UBC Theses and Dissertations
The effect of early diet on hepatic cholesterol metabolism in piglets Devlin, Angela Marie
Abstract
Plasma total, low density lipoprotein (LDL) and high density lipoprotein (HDL) cholesterol concentrations increase immediately following birth. Interestingly, this increase is greater in breast-fed infants than in infants fed formula. The reason(s) why there are differences in plasma cholesterol concentrations between breast-fed and formula-fed infants is not known. However, this difference may be a consequence of the variations in lipid composition between milk and infant formula. Little is known regarding the specific effects of the lipid component(s) of infant diets on the expression of genes involved in hepatic lipid metabolism. The studies presented in this thesis determined whether the addition of cholesterol, arachidonic acid [20:4(n-6)] and docosahexaenoic acid [22:6(n-3)] to formula, and the positional distribution of fatty acids in formula triglycerides increases plasma cholesterol in formula-fed piglets to levels observed in milk-fed piglets. In study #1, piglets were fed from birth to 18 days of age with either a conventional infant formula (conventional formula) or a formula with synthesized triglycerides (TG) (synthesized TG formula). The conventional infant formula had 70% of the total 16:0, representing 23% of total fatty acids, esterified at the sn-1 and 3 positions of the formula triglyceride. The synthesized TG formula contained a similar percentage of 16:0, representing 23% of total fatty acids, but had 47% of the total 16:0 esterified at the centre (sn-2) position of the formula triglyceride. Each of the conventional and synthesized TG formulae were provided either without (
Item Metadata
| Title |
The effect of early diet on hepatic cholesterol metabolism in piglets
|
| Creator | |
| Publisher |
University of British Columbia
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| Date Issued |
1998
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| Description |
Plasma total, low density lipoprotein (LDL) and high density lipoprotein (HDL)
cholesterol concentrations increase immediately following birth. Interestingly, this
increase is greater in breast-fed infants than in infants fed formula. The reason(s) why
there are differences in plasma cholesterol concentrations between breast-fed and
formula-fed infants is not known. However, this difference may be a consequence of
the variations in lipid composition between milk and infant formula. Little is known
regarding the specific effects of the lipid component(s) of infant diets on the expression
of genes involved in hepatic lipid metabolism. The studies presented in this thesis
determined whether the addition of cholesterol, arachidonic acid [20:4(n-6)] and
docosahexaenoic acid [22:6(n-3)] to formula, and the positional distribution of fatty acids
in formula triglycerides increases plasma cholesterol in formula-fed piglets to levels
observed in milk-fed piglets. In study #1, piglets were fed from birth to 18 days of age
with either a conventional infant formula (conventional formula) or a formula with
synthesized triglycerides (TG) (synthesized TG formula). The conventional infant
formula had 70% of the total 16:0, representing 23% of total fatty acids, esterified at the
sn-1 and 3 positions of the formula triglyceride. The synthesized TG formula contained
a similar percentage of 16:0, representing 23% of total fatty acids, but had 47% of the
total 16:0 esterified at the centre (sn-2) position of the formula triglyceride. Each of the
conventional and synthesized TG formulae were provided either without (
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| Extent |
11812106 bytes
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| Genre | |
| Type | |
| File Format |
application/pdf
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| Language |
eng
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| Date Available |
2009-06-18
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| Provider |
Vancouver : University of British Columbia Library
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| Rights |
For non-commercial purposes only, such as research, private study and education. Additional conditions apply, see Terms of Use https://open.library.ubc.ca/terms_of_use.
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| DOI |
10.14288/1.0076786
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| URI | |
| Degree | |
| Program | |
| Affiliation | |
| Degree Grantor |
University of British Columbia
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| Graduation Date |
1998-11
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| Campus | |
| Scholarly Level |
Graduate
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| Aggregated Source Repository |
DSpace
|
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Rights
For non-commercial purposes only, such as research, private study and education. Additional conditions apply, see Terms of Use https://open.library.ubc.ca/terms_of_use.