UBC Theses and Dissertations
Some intermediaries for the synthesis of [beta]-(-3-methoxy-4-hydroxy-phenyl)-[beta]-hydroxyethylamine. Part I Hamilton, John Kelvin
In the first of three syntheses vanillin is converted to benzoyl vanillic acid, then successively to the acyl chloride, cyanide with subsequent reduction to the amine. The second method involves the synthesis of vanillin cyanohydrin followed by reduction to the amine. The third method involves the Fries rearrangement of guaiacol acetate followed by bromination of the acetophenone and conversion to the amine.
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