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Amide hydrolysis in vitamin B12 Raleigh, James Arthur

Abstract

Six alicyclic amides which simulate the steric environment of the amide groupings in vitamin B12 have been prepared and their rates of alkaline hydrolysis compared on the basis of second order apparent rate constants. In addition, vitamin B12b, a simple derivative of vitamin B12, has been prepared and hydrolyzed under the same conditions as for the model compounds.

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