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Amide hydrolysis in vitamin B12 Raleigh, James Arthur

Abstract

Six alicyclic amides which simulate the steric environment of the amide groupings in vitamin B12 have been prepared and their rates of alkaline hydrolysis compared on the basis of second order apparent rate constants. In addition, vitamin B12b, a simple derivative of vitamin B12, has been prepared and hydrolyzed under the same conditions as for the model compounds.

Item Metadata

Title
Amide hydrolysis in vitamin B12
Creator
Raleigh, James Arthur
Publisher
University of British Columbia
Date Issued
1962
Description
Six alicyclic amides which simulate the steric environment of the amide groupings in vitamin B12 have been prepared and their rates of alkaline hydrolysis compared on the basis of second order apparent rate constants. In addition, vitamin B12b, a simple derivative of vitamin B12, has been prepared and hydrolyzed under the same conditions as for the model compounds.
Genre
Thesis/Dissertation
Type
Text
Language
eng
Date Available
2011-12-02
Provider
Vancouver : University of British Columbia Library
Rights
For non-commercial purposes only, such as research, private study and education. Additional conditions apply, see Terms of Use https://open.library.ubc.ca/terms_of_use.
DOI
10.14288/1.0062122
URI
http://hdl.handle.net/2429/39474
Degree
Master of Science - MSc
Program
Chemistry
Affiliation
Science, Faculty of; Chemistry, Department of
Degree Grantor
University of British Columbia
Campus
UBCV
Scholarly Level
Graduate
Aggregated Source Repository
DSpace

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Rights

For non-commercial purposes only, such as research, private study and education. Additional conditions apply, see Terms of Use https://open.library.ubc.ca/terms_of_use.