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UBC Theses and Dissertations

Synthesis of aza steroids. Part I. The synthesis of 6-aza steroids. Part II. The synthesis of 11-aza steroids Vlattas, Isidoros

Abstract

Ozonization of 7-ketocholesteryl acetate has yielded methyl 5-keto-5, 7-seco-6-nor-3-cholestene-7-oate in reasonably high yield. This intermediate was converted by catalytic hydrogenation to methyl-5-keto-5, 7-seco-6-norcholestan-7-oate which upon treatment with benzyl amine gave N-benzyl-6-aza-4-cholesten-7-one.

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