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Polyketide secondary metabolites of the Dominican sponge Plakortis angulospiculatus Porter, Justin M.J.

Abstract

As part of a search for new antifungal agents, the polyketide cyclic peroxides, compounds 32 and 33, were isolated from the Dominican sponge Plakortis angulospiculatus. Both compounds showed potent in vitro activity against Candida albicans. Chemical genetic profiling of the crude sponge extract and compound 33 indicated a non-specific mode of action against the yeast, Saccharomyces cerevisiae. Further exploration of the sponge extract yielded two furano polyketides, the newly discovered α,β-unsaturated ester, 37, and the previously isolated compound, glanvillic acid B (38). The structures were elucidated by one- and two-dimensional spectroscopic analysis of 32,33,37, and 38. [Chemical Diagrams]

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