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Effect of atmospheric pressure ion lens on an electrospray ion source Yi, Rong
Abstract
The effect of an atmospheric pressure ion lens on electrospray ionization mass spectrometry (ESI-MS) was investigated. In Chapter 2, the voltage combinations applied to the spray and the ion lens were systematically studied, as well as the current-voltage relationship. The ion lens showed its ability to widen the range of operational spray voltages and improve signal intensity. Through the calculations in Chapter 3, the effect ofthe ion lens is demonstrated to include improving the electrospray process by changing the field strength and widening the operational spray voltage range, and increasing the transmission efficiency by focusing ions through the flattened equipotential lines. The experimental results in Chapter 2 were rationalized, and the hypotheses were verified. In Chapter 4, more experiments were carried out to show solvent dependence, nebulizer optimization, and fragmentation control for the characterization of ESI-MS. Future work was proposed to combine the ion lens with a multiple-spray ion source, where the ion lens has the potential to improve the sensitivity of the ion source, and to simultaneously introduce a mass calibrant to improve the mass accuracy of mass spectrometry.
Item Metadata
Title |
Effect of atmospheric pressure ion lens on an electrospray ion source
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Creator | |
Publisher |
University of British Columbia
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Date Issued |
2005
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Description |
The effect of an atmospheric pressure ion lens on electrospray ionization mass
spectrometry (ESI-MS) was investigated. In Chapter 2, the voltage combinations applied to the
spray and the ion lens were systematically studied, as well as the current-voltage relationship.
The ion lens showed its ability to widen the range of operational spray voltages and improve
signal intensity. Through the calculations in Chapter 3, the effect ofthe ion lens is demonstrated
to include improving the electrospray process by changing the field strength and widening the
operational spray voltage range, and increasing the transmission efficiency by focusing ions
through the flattened equipotential lines. The experimental results in Chapter 2 were
rationalized, and the hypotheses were verified. In Chapter 4, more experiments were carried out
to show solvent dependence, nebulizer optimization, and fragmentation control for the
characterization of ESI-MS. Future work was proposed to combine the ion lens with a
multiple-spray ion source, where the ion lens has the potential to improve the sensitivity of the
ion source, and to simultaneously introduce a mass calibrant to improve the mass accuracy of
mass spectrometry.
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Genre | |
Type | |
Language |
eng
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Date Available |
2009-12-18
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Provider |
Vancouver : University of British Columbia Library
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Rights |
For non-commercial purposes only, such as research, private study and education. Additional conditions apply, see Terms of Use https://open.library.ubc.ca/terms_of_use.
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DOI |
10.14288/1.0061158
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URI | |
Degree | |
Program | |
Affiliation | |
Degree Grantor |
University of British Columbia
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Graduation Date |
2005-11
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Campus | |
Scholarly Level |
Graduate
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Aggregated Source Repository |
DSpace
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Item Media
Item Citations and Data
Rights
For non-commercial purposes only, such as research, private study and education. Additional conditions apply, see Terms of Use https://open.library.ubc.ca/terms_of_use.