UBC Theses and Dissertations

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UBC Theses and Dissertations

The conformationally controlled alkylation of 15-hexadecanolide Graham, Ronald Joseph


The 16-membered lactone 17was synthesized and alkylated to yield a 4:1 ratio of 20 and 19 respectively. The product ratio was rationalized by molecular mechanics calculations on 18. A new polar map convention was developed for conformational analysis of cyclohexadecane.[See Thesis for Diagram]

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