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UBC Theses and Dissertations

The design and synthetic studies of N ∝-[1-(carboxy)-9,11,21-(trioxo)-heneicosyl]-l-aspartyl-l-lysyl-(tert-butyl)-l-asparaginate, a tripeptide analogue of ionomycin Putland, Michael Stuart


Ionomycin is a stereochemically complex calcium ionophore. An analogue (34) of ionomycin has been designed and its synthesis initiated. Regions of the analogue which parallel portions of ionomycin do not incorporate any of the chiral centers found in the natural product. The analogue 34 also incorporates a highly conserved tripeptide found in the calcium binding site of troponin C proteins. [ Formula omitted ]

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