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Aqueous chemistry of vanadium complexes of therapeutic interest Glover, Nicholas
Abstract
The aqueous chemistry of bis(maltolato)oxovanadium(IV), VO(ma)₂, bis(kojato)oxovandium(IV, VO(ka)₂, and bis(maltolato)dioxovandate(V), [VO₂(ma)₂] were studied as part of a research interest regarding their potential as insulin mimetic therapeutic agents. UV-Visible spectroscopy provided information regarding changes in the immediate vanadium environment with variable pH, and determined that oxidation of VO(ma)₂ and VO(ka)₂ occurs upon exposure to air. Variable pH cyclic voltammetric electrochemical investigation of the compounds of interest revealed that only VO(ma)₂ displayed reversible electrochemical behaviour. Room temperature and frozen solution ESR spectral parameters for the complexes were determined. Reduction of [VO₂(ma)₂]⁻ to VO(ma)₂ in acidic solution was determined by ESR spectroscopy. ⁵¹V NMR spectroscopy was used to probe the type, and stoichiometry, of complexes present in aqueous solution as a function of pH. Oxidation of VO(ma)₂ and VO(ka)₂ to vanadium(V) complexes was proven by ⁵¹V NMR spectra. Potentiometric titrations were used to determine ligand protonation constants, and metal-ligand stability constants.
Item Metadata
| Title |
Aqueous chemistry of vanadium complexes of therapeutic interest
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| Creator | |
| Publisher |
University of British Columbia
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| Date Issued |
1993
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| Description |
The aqueous chemistry of bis(maltolato)oxovanadium(IV), VO(ma)₂, bis(kojato)oxovandium(IV, VO(ka)₂, and bis(maltolato)dioxovandate(V), [VO₂(ma)₂] were studied as part of a research interest regarding their potential as insulin mimetic therapeutic agents. UV-Visible spectroscopy provided information regarding changes in the immediate vanadium environment with variable pH, and determined that oxidation of VO(ma)₂ and VO(ka)₂ occurs upon exposure to air. Variable pH cyclic voltammetric electrochemical investigation of the compounds of interest revealed that only VO(ma)₂ displayed reversible electrochemical behaviour. Room temperature and frozen solution ESR spectral parameters for the complexes were determined. Reduction of [VO₂(ma)₂]⁻ to VO(ma)₂ in acidic solution was determined by ESR spectroscopy. ⁵¹V NMR spectroscopy was used to probe the type, and stoichiometry, of complexes present in aqueous solution as a function of pH. Oxidation of VO(ma)₂ and VO(ka)₂ to vanadium(V) complexes was proven by ⁵¹V NMR spectra. Potentiometric titrations were used to determine ligand protonation constants, and metal-ligand stability constants.
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| Extent |
2534248 bytes
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| Genre | |
| Type | |
| File Format |
application/pdf
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| Language |
eng
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| Date Available |
2009-02-20
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| Provider |
Vancouver : University of British Columbia Library
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| Rights |
For non-commercial purposes only, such as research, private study and education. Additional conditions apply, see Terms of Use https://open.library.ubc.ca/terms_of_use.
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| DOI |
10.14288/1.0059504
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| URI | |
| Degree | |
| Program | |
| Affiliation | |
| Degree Grantor |
University of British Columbia
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| Graduation Date |
1994-05
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| Campus | |
| Scholarly Level |
Graduate
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| Aggregated Source Repository |
DSpace
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Rights
For non-commercial purposes only, such as research, private study and education. Additional conditions apply, see Terms of Use https://open.library.ubc.ca/terms_of_use.