The Open Collections website will be undergoing maintenance on Wednesday December 7th from 9pm to 11pm PST. The site may be temporarily unavailable during this time.

UBC Theses and Dissertations

UBC Theses Logo

UBC Theses and Dissertations

Mechanical response of reconstituted, freeze-dried collagen under compression loads Khosla, Amardeep Singh


The mechanical response under uniaxial compression of collagen discs, made from freeze-dried collagen reconstituted at acid pH, was investigated at 22, 29.5, and 35°C (±0.3 C°). The pH during compression was maintained near the physiological level of 7.40-5. Connective tissues are known to be non-linear viscoelastic materials. It was felt, however, that the linearized, fluid transport-based model developed by Bert (1970) would adequately describe the behaviour of collagen "for small changes in hydration. [The model is linearized through the assumption that the diffusion coefficient, D(H), is a weak function of hydration, and is therefore constant for small changes in hydration]. The average diffusion coefficient, D(H), and the flow condictivity,k/n, were found to be stronger functions of hydration than expected in the hydration range investigated [1.9 to 5.5 g H₂O/g collagen], and this may have increased scatter in the results. Average values of D(H) and k/n at hydration 3.0 g H₂O/g collagen [i.e. skin hydration] were ~ 3.5x10⁻⁷cm²/s and ~ 6.0x10⁻¹¹cm⁴/dyne-s respectively. The compressive response of collagen was only weakly influenced by temperature, and possible thermal degradation of the molecules was indicated at 35°C. Some creep was also noted at times >5 t[sub ½], but no attempt was made to quantify it.

Item Media

Item Citations and Data


For non-commercial purposes only, such as research, private study and education. Additional conditions apply, see Terms of Use