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Assessing the adherence and acceptability to iron and folic acid compared with multiple micronutrient supplements during pregnancy : a cluster-randomized non-inferiority trial in Cambodia Sauer, Cassandra

Abstract

Background: The Cambodian Ministry of Health is exploring transitioning from iron and folic acid (IFA) to multiple micronutrient supplements (MMS) during pregnancy and is seeking rigorous evidence to inform this policy change. Objective: We aimed to assess the adherence and acceptability of MMS compared with IFA supplementation during pregnancy. Methods: We conducted an open-label cluster-randomized non-inferiority trial across 48 health centers (clusters) in Cambodia. A total of 1,546 healthy pregnant individuals (18-45 years) were recruited at their first antenatal care (ANC) visit (

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Attribution-NonCommercial-NoDerivatives 4.0 International