Open Collections

Hu, Yujie

University of British Columbia

Research and surgery in ophthalmology demand precise details about ocular tissues to study the causes of diseases, examine possible therapies, and assess the suitability of donated tissues. Mouse were commonly studied in preclinical research, which offers significant benefits as research subjects due to their ready availability and the wide array of pathological models they represent. Meanwhile, human corneal transplants require a comprehensive examination of the donor cornea to guarantee the success of the transplant. Optical coherence tomography (OCT) is a noninvasive imaging method that captures high-resolution three-dimensional structures. It has been extensively used in ophthalmology for several years and has progressed to provide details such as cellular structures, melanin distribution, and vascular distribution for ocular tissues. The thesis explores two micro-optical coherence tomography systems in NIR and VIS. Utilizing these two systems, the study examined the mouse model and human and obtained cellular-resolution images of the posterior segment of the eye. These images offer crucial insights for understanding eye diseases and assessing potential treatment approaches. Additionally, high-resolution images of mouse and human corneas were captured to assess the integration of corneal layers and to help increase the effectiveness of corneal transplant procedures.

Text

2024-08-22

Attribution-NonCommercial-NoDerivatives 4.0 International

http://hdl.handle.net/2429/89009

Biomedical Engineering

University of British Columbia

UBCV

http://creativecommons.org/licenses/by-nc-nd/4.0/