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Regional cerebral metabolic rate of oxygen and levels of respiratory support in preterm neonates Zhu, Chen Shuang
Abstract
Background: Preterm birth is associated with a higher rate of brain injury and neurodevelopmental delays in children. The brain is dependent on oxidative metabolism of glucose to meet its significant energy requirements. Understanding the cerebral metabolic rate of oxygen (CMRO₂) and how it is affected by ventilation in the neonatal population is crucial to the advancement of neonatal medicine. This study aims to assess the feasibility of quantifying CMRO₂ and cerebral blood flow (CBF) using magnetic resonance imaging (MRI) in preterm infants at term equivalent age (TEA) and to determine how various ventilatory support may affect CMRO₂. We hypothesized that increased time on mechanical ventilation would be negatively associated with CMRO2 and CBF levels in preterm neonates at TEA. Methods: Very preterm neonates (n=19) born
Item Metadata
| Title |
Regional cerebral metabolic rate of oxygen and levels of respiratory support in preterm neonates
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| Creator | |
| Supervisor | |
| Publisher |
University of British Columbia
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| Date Issued |
2023
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| Description |
Background: Preterm birth is associated with a higher rate of brain injury and neurodevelopmental delays in children. The brain is dependent on oxidative metabolism of glucose to meet its significant energy requirements. Understanding the cerebral metabolic rate of oxygen (CMRO₂) and how it is affected by ventilation in the neonatal population is crucial to the advancement of neonatal medicine. This study aims to assess the feasibility of quantifying CMRO₂ and cerebral blood flow (CBF) using magnetic resonance imaging (MRI) in preterm infants at term equivalent age (TEA) and to determine how various ventilatory support may affect CMRO₂. We hypothesized that increased time on mechanical ventilation would be negatively associated with CMRO2 and CBF levels in preterm neonates at TEA.
Methods: Very preterm neonates (n=19) born
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| Genre | |
| Type | |
| Language |
eng
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| Date Available |
2023-08-28
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| Provider |
Vancouver : University of British Columbia Library
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| Rights |
Attribution-NonCommercial-NoDerivatives 4.0 International
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| DOI |
10.14288/1.0435605
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| URI | |
| Degree (Theses) | |
| Program (Theses) | |
| Affiliation | |
| Degree Grantor |
University of British Columbia
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| Graduation Date |
2023-11
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| Campus | |
| Scholarly Level |
Graduate
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| Rights URI | |
| Aggregated Source Repository |
DSpace
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Rights
Attribution-NonCommercial-NoDerivatives 4.0 International