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UBC Theses and Dissertations

The effect of oxygen supplementation on brachial artery hemodynamics and vascular function during trekking ascent to high altitude Vizcardo-Galindo, Gustavo

Abstract

High altitude trekking alters upper limb hemodynamics and reduces brachial artery vascular function in lowlanders. However, whether these changes are reversible with the correction of hypoxia is unknown. We investigated the impact of 15 minutes of oxygen supplementation (O₂) on brachial artery hemodynamics, reactive hyperemia (microvascular function) and flow-mediated dilation (FMD; endothelial function). Healthy male participants (aged 21-42 years) were examined prior to and with O₂ at 3440m (day 4 at high altitude; n=7), 4371m (day 7; n=7), and 5050m (day 10; n=12) using Duplex ultrasound. At 3440m, O₂ decreased brachial artery diameter (-5±5%; P=0.04), baseline blood flow (-44±15%; P

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Attribution-NonCommercial-NoDerivatives 4.0 International