The Open Collections website will be undergoing maintenance on Wednesday December 7th from 9pm to 11pm PST. The site may be temporarily unavailable during this time.

UBC Theses and Dissertations

UBC Theses Logo

UBC Theses and Dissertations

HSP90 contributes to chs3-2D-mediated autoimmunity Zhang, Nanbing


Plants employ multi-layered immune systems against infections by various pathogens. Different receptors in plants are able to detect the invasion activities caused by pathogens, transduce signals to downstream components, and activate defense responses. Among them, nucleotide-binding domain leucine-rich repeat containing proteins (NLRs) are the major intracellular immune receptor proteins. CHILLING SENSITIVE 3 (CHS3) is one of the NLRs with an additional Lin-11, Isl-1 and Mec-3 (LIM) domain at its C terminus. The gain-of-function mutant, chs3-2D, exhibiting severe dwarfism and constitutively activated defense responses, was selected as a genetic background in this study for a forward genetic screen. An allele of hsp90.2 was isolated as a partial suppressor of chs3-2D, which suggests that HSP90.2 is a positive regulator of CHS3-mediated defense signaling. In addition, HSP90s are also either fully or partially required for the autoimmunity of Dominant Negative (DN) SNIPER1 and gain-of-function ADR1 mutants, suggesting a broader role of HSP90 in NLR-mediated defense. Overall, my thesis work dissecting the CHS3-mediated autoimmunity may assist the future development of crop disease control in a more sustainable way.

Item Media

Item Citations and Data


Attribution-NonCommercial-NoDerivatives 4.0 International