UBC Theses and Dissertations

UBC Theses Logo

UBC Theses and Dissertations

Synthesis of 2,3-disubstituted azaindoles using copper catalysts Shen, Yue


The copper catalyzed reaction between 2-amino-3-halopyridines and 𝛽-dicarbonyl and related compounds was investigated. Twelve examples of azaindoles synthesis was observed in yields varying from 10-80%. The reaction of 𝛽-keto sulfones was complicated by the formation of 3-(phenylsulfonyl)pyridin-2-amine as a coproduct. Experiments to determine the timing of bond forming events were conducted, although synthetic challenges using amino substituted pyridines complicated these studies.

Item Media

Item Citations and Data


Attribution-NonCommercial-NoDerivatives 4.0 International