UBC Theses and Dissertations
Synthesis of 2,3-disubstituted azaindoles using copper catalysts Shen, Yue
The copper catalyzed reaction between 2-amino-3-halopyridines and 𝛽-dicarbonyl and related compounds was investigated. Twelve examples of azaindoles synthesis was observed in yields varying from 10-80%. The reaction of 𝛽-keto sulfones was complicated by the formation of 3-(phenylsulfonyl)pyridin-2-amine as a coproduct. Experiments to determine the timing of bond forming events were conducted, although synthetic challenges using amino substituted pyridines complicated these studies.
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