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UBC Theses and Dissertations

A novel lower limb resistance training program to reduce dyspnea in patients with chronic obstructive pulmonary disease Brunton, Nicole Michelle


Background: Skeletal muscle disuse, dysfunction and atrophy are important extrapulmonary complications of COPD that contribute to exercise intolerance and increase the intensity of dyspnea through enhanced stimulation of type III/IV muscle afferents. As such, performing aerobic exercise training as part of pulmonary rehabilitation (PR) is difficult because patients are often unable to tolerate the intensity and/or volume of exercise required to achieve clinically important benefits. Resistance training (RT) is an attractive exercise modality as it improves skeletal muscle strength and efficiency and is often more tolerable initially. However, whether individualized RT can reduce dyspnea, leg fatigue, and enhance exercise tolerance in patients with COPD has not been studied. Methods: For this single-armed efficacy study, eight non-smoking patients with COPD (FEV₁/FVC

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