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UBC Theses and Dissertations

Efficacy, safety and post-treatment comfort of cyanoacrylate as an adjunct to non-surgical periodontal therapy : a pilot randomized clinical trial Chaturvedi, Rashi


Objectives: Non-surgical periodontal therapy (NSPT) can be associated with post-treatment complications of gingival tissue tenderness and teeth sensitivity that can negatively impact oral self-care thereby significantly affecting periodontal wound healing in its critical phase. The ineffectiveness of biofilm disruption can also further increase the sensitivity of gingival tissues and teeth resulting in patient’s reluctance in continuing regular oral self-care and professional therapy. This pilot split-mouth blinded randomized clinical trial assessed the efficacy of supra-gingival application of cyanoacrylate adhesive (PeriAcryl®90HV) in promoting periodontal wound healing and preventing increased sensitivity of teeth and gingival tissues following NSPT. Methods: 24 participants with active periodontal disease were recruited. Two selected quadrants with symmetrical disease were randomly divided into experimental and control arms and received NSPT. The experimental sites additionally received an application of cyanoacrylate adhesive (PeriAcryl®90HV) extending 1-2mm along gingival margins. Primary and secondary endpoints included clinical attachment level (CAL), bleeding on probing (BOP), probing depth (PD) and plaque score (PI), from baseline to the final visit at 6-8 weeks following NSPT. Furthermore, teeth sensitivity and pain and gingival tissue discomfort at baseline, 1-week and the final visit at 6-8 weeks following NSPT were ascertained using the visual analogue scale (VAS) and daily journaling. Receptiveness to future application of the cyanoacrylate adhesive was also evaluated using VAS. Results: The application of cyanoacrylate after NSPT resulted in no statistical changes between arms for CAL, PD, PI and sensitivity from baseline to the final visit at 6-8 weeks. BOP reduction was statistically significant (p=0.003*) in the experimental arm. The application of cyanoacrylate had no adverse events and was found highly acceptable (69.6%; n=16/23) by the subjects. Conclusions: The reduction of BOP in the study indicates, that the application of cyanoacrylate with its antimicrobial traits and treatment acceptance, may serve as a useful adjunct to NSPT in reducing gingival inflammation.  

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