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Cerebrovascular and ventilatory responses to acute normobaric hypoxia in girls and women Morris, Laura

Abstract

Physiological responses to hypoxia in children are incompletely understood. We aimed to characterize cerebrovascular and ventilatory responses to normobaric hypoxia in girls and women. Methods: Ten healthy girls (9.9 +/- 1.7y; mean +/- SD; Tanner stage 1 and 2) and their mothers (43.9 +/- 3.5y) participated. Internal carotid (ICA) and vertebral artery (VA) velocity, diameter and flow (Duplex ultrasound) was recorded pre- and post-1h of hypoxic exposure (FIO₂=0.126;~4000m) in a normobaric chamber. Ventilation (VE) and respiratory drive (VT/TI) expressed as delta change from baseline (∆%), and end-tidal carbon-dioxide (PETCO₂) were collected at baseline (BL) and 5, 30 and 60 minutes of hypoxia (5/30/60 HYP). Heart rate (HR) and oxygen saturation (SpO₂) were also collected at these time-points. Results: SpO₂ declined similarly in girls (BL-97%; 60HYP-80%, P

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