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Vitamin B-12 status during pregnancy and infancy : screening tools and assessment of populations at risk for deficiency Schroder, Theresa H.
Abstract
Low perinatal and infantile vitamin B-12 (B-12) status have been associated with health complications. South Asians and residents of low- and middle-income countries may be at increased risk for low B-12 status. The overall goal was to facilitate and screen for perinatal, neonatal, and infantile B-12 status. First, a reliable (recovery: 93–98%; CV: 29.3 pmol/8-mm punch was computed per clinical guidelines (CLSI EP18-A3c). Further, B-12 status of South Asian and European pregnant women and their newborns living in Vancouver were compared. B-12 status was assessed in 748 healthy Vancouver women (50% South Asian, 50% European) during their 1st and 2nd trimester of pregnancy using multiple B-12 biomarkers, and in their newborns using DBS MMA concentration. South Asian pregnant women had a significantly lower B-12 status than European women, e.g. comparing 1st trimester mean (95% CI) serum total B-12 concentrations [189 (180; 199) pmol/L versus 246 (236; 257) pmol/L; P
Item Metadata
Title |
Vitamin B-12 status during pregnancy and infancy : screening tools and assessment of populations at risk for deficiency
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Creator | |
Publisher |
University of British Columbia
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Date Issued |
2017
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Description |
Low perinatal and infantile vitamin B-12 (B-12) status have been associated with health complications. South Asians and residents of low- and middle-income countries may be at increased risk for low B-12 status.
The overall goal was to facilitate and screen for perinatal, neonatal, and infantile B-12 status. First, a reliable (recovery: 93–98%; CV: 29.3 pmol/8-mm punch was computed per clinical guidelines (CLSI EP18-A3c). Further, B-12 status of South Asian and European pregnant women and their newborns living in Vancouver were compared. B-12 status was assessed in 748 healthy Vancouver women (50% South Asian, 50% European) during their 1st and 2nd trimester of pregnancy using multiple B-12 biomarkers, and in their newborns using DBS MMA concentration. South Asian pregnant women had a significantly lower B-12 status than European women, e.g. comparing 1st trimester mean (95% CI) serum total B-12 concentrations [189 (180; 199) pmol/L versus 246 (236; 257) pmol/L; P
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Genre | |
Type | |
Language |
eng
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Date Available |
2020-05-31
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Provider |
Vancouver : University of British Columbia Library
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Rights |
Attribution-NonCommercial-NoDerivatives 4.0 International
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DOI |
10.14288/1.0344022
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URI | |
Degree | |
Program | |
Affiliation | |
Degree Grantor |
University of British Columbia
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Graduation Date |
2017-05
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Campus | |
Scholarly Level |
Graduate
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Rights URI | |
Aggregated Source Repository |
DSpace
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Rights
Attribution-NonCommercial-NoDerivatives 4.0 International