Open Collections

Stacked graphs and symmetric groups : modelling the conformation space of nucleic acids

University of British Columbia

This work introduces a technique for approximating the conformation space of rigid and semi-rigid kinematic chains with finite inverse kinematic solutions using graph-like constructs called stacked graphs. The technique is developed in the context of nucleic acids, in particular ribonucleic acid (RNA), whose phosphate backbone can be modelled as a kinematic chain. Additionally, a process for identifying stable RNA conformations and likely conformational pathways is demonstrated. As a secondary result, a potentially novel relationship between stacked graphs and symmetric groups is uncovered and briefly investigated.

Text

2017-04-11

Attribution-NonCommercial-NoDerivatives 4.0 International

http://hdl.handle.net/2429/61177

Interdisciplinary Studies

University of British Columbia

UBCO

http://creativecommons.org/licenses/by-nc-nd/4.0/