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UBC Theses and Dissertations

The Role of the p75 neurotrophin receptor in regulating oligodendrocyte progenitor cell differentiation Bedard, Simon


One major avenue towards repair of the damaged mammalian nervous system is an enhancement of the process known as remyelination. This process restores to damaged neurons the protective sheath that is critical not only for their survival but also for the conduction of their electrical signals. However, remyelination is inhibited after many types of nervous system damage as well as in degenerative diseases of the nervous system. This inhibition functions primarily through prevention of the capacity of progenitor cells to become remyelinating cells. This work aims to address the role that the p75 neurotrophin receptor (p75) – an important signalling protein that stands at the intersection of several key signalling cascades – plays in mediating this inhibition of remyelination. The intention of this work is to investigate p75 as a potential therapeutic target for clinical interventions aimed at enhancing remyelination.

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