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UBC Theses and Dissertations

The cardiovascular, respiratory, systemic, and autonomic responses to exercise in diesel exhaust Giles, Luisa


Purpose: To determine the cardiovascular, respiratory, systemic inflammatory, and autonomic nervous system responses to varying exercise intensities during exposure to diesel exhaust (DE), and to determine how DE exposure before exercise affects the cardio-respiratory system and subsequent exercise performance. Methods: Eighteen males performed six 30-minute trials, which included rest, low-intensity, and high-intensity cycling. Each trial was performed twice, once breathing filtered air (FA) and once breathing DE (300ug/m³ of PM₂.₅) with seven days between trials. Before, and following exercise, exhaled nitric oxide, pulmonary function, heart rate variability, flow-mediated dilation (FMD), complete blood count, endothelin-¹ , and plasma nitrite/nitrate (NOx) were measured. During exercise, minute ventilation (VE), oxygen consumption (VO₂), CO₂ production (VCO₂), respiratory exchange ratio (RER), and rating of perceived exertion (RPE) for lungs and legs were measured. In a second experiment, eight males were exposed to DE (300ug/m³ of PM₂.₅) or FA for 60-minutes, followed by an indoor 20-km cycling time trial. Pulmonary function was assessed before and after exposure and after exercise. Heart rate was measured during exposure and exercise performance was measured as mean power output during exercise. Results: In the first experiment, RER was significantly lower (0.94 vs. 0.96), and RPE significantly greater, in DE compared to FA (p

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