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UBC Theses and Dissertations
A minimally-invasive MEMS drug delivery device for the treatment of prostate cancer Zachkani, Payam
Abstract
We have developed a cylindrical shape magnetically-actuated MEMS drug delivery device for localized prostate cancer treatment. The device is small enough for implantation through a needle with minimally invasive procedures with potentially fewer side effects compared with full prostate removal. This method of implantation will be similar to brachytherapy, a standard procedure to implant radioactive seeds inside the prostate through a needle. The drug delivery device consists of a drug reservoir, a PDMS membrane, a magnetic block and housing. Docetaxel (DTX), an anti-proliferative drug, is deposited in the reservoir in solid form. The reservoir is then filled with fluids to form a saturated drug solution. When an external magnetic field is applied, it attracts the magnetic block towards the positive field gradient and causes the membrane to deflect. As a result, DTX is discharged from the reservoir, through a laser-drilled aperture on the membrane and into the housing. The housing has a 10 mm long opening which allows the released drug to diffuse to the surrounding tissues while it would prevent the tissues from touching the thin membrane. We have achieved a 1.8 fold increase of the actuating distance and a 3.6 fold increase in the magnetic force compared to the state-of-the-art magnetically-actuated drug delivery devices under the same actuation parameters. We have also demonstrated device implantation with a needle into swine bladder tissue and successful drug release of the device in the tissue.
Item Metadata
Title |
A minimally-invasive MEMS drug delivery device for the treatment of prostate cancer
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Creator | |
Publisher |
University of British Columbia
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Date Issued |
2014
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Description |
We have developed a cylindrical shape magnetically-actuated MEMS drug delivery device for localized prostate cancer treatment. The device is small enough for implantation through a needle with minimally invasive procedures with potentially fewer side effects compared with full prostate removal. This method of implantation will be similar to brachytherapy, a standard procedure to implant radioactive seeds inside the prostate through a needle.
The drug delivery device consists of a drug reservoir, a PDMS membrane, a magnetic block and housing. Docetaxel (DTX), an anti-proliferative drug, is deposited in the reservoir in solid form. The reservoir is then filled with fluids to form a saturated drug solution. When an external magnetic field is applied, it attracts the magnetic block towards the positive field gradient and causes the membrane to deflect. As a result, DTX is discharged from the reservoir, through a laser-drilled aperture on the membrane and into the housing. The housing has a 10 mm long opening which allows the released drug to diffuse to the surrounding tissues while it would prevent the tissues from touching the thin membrane.
We have achieved a 1.8 fold increase of the actuating distance and a 3.6 fold increase in the magnetic force compared to the state-of-the-art magnetically-actuated drug delivery devices under the same actuation parameters. We have also demonstrated device implantation with a needle into swine bladder tissue and successful drug release of the device in the tissue.
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Genre | |
Type | |
Language |
eng
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Date Available |
2015-06-30
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Provider |
Vancouver : University of British Columbia Library
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Rights |
Attribution-NonCommercial-NoDerivs 2.5 Canada
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DOI |
10.14288/1.0135633
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URI | |
Degree | |
Program | |
Affiliation | |
Degree Grantor |
University of British Columbia
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Graduation Date |
2015-02
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Campus | |
Scholarly Level |
Graduate
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Rights URI | |
Aggregated Source Repository |
DSpace
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Item Citations and Data
Rights
Attribution-NonCommercial-NoDerivs 2.5 Canada