UBC Theses and Dissertations
Mathematical models for immunodeficiency virus : post-treatment and memory activation Herrera Reyes, Alejandra Donaji
Nowdays, HIV infection can be controlled by anti-retroviral drug therapy (ART). However, a persistent viral reservoir in treated patients prevents the eradication of HIV infection. H-iART is an innovator treatment that consists of regular ART and the drugs Maraviroc and Darunavir, and H-iART was enforced with Auranofin. The drug Maraviroc (MRV) was proved to be a good CCR5 inhibitor, which is a HIV correceptor. The drug Auranofin has been shown to accelerate the activation rate of latent cells and also alters the kinetics of viral rebound when drug treatment is interrupted. Recent studies on monkeys infected with SIV have shown a complete suppression of the viral load during H-iART with Auranofin treatment and a persistent suppression of it in the absence of ART. Motivated by the results of the experiments I present deterministic and stochastic models of HIV after treatment interruption. For H-iART treatment, the ODE models were used as a start point to create three different continuous time multi-type branching process. From equations for the probability generating function we use analytic solutions, numerical approximations, or numerical simulations to extract the probability of observable viral blips. We compare our results with the data of two rhesus macaques. We find that more than one latent cell needs to activate in order to observe the data blips, and that the net reproductive number of virus must be very close to one. Since this is unlikely, these results suggest that the viral dynamics must be more complex than our model allows for. For the ART+Auranofin treatment, I will present an ODE model of HIV population dynamics including drug treatment and the immune response to model the viral rebound at treatment interruption.
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