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UBC Theses and Dissertations

Fitness status and post-exercise inflammatory markers in 18-35-year-old males Rose, Peter Geoffrey Donald


Acute physical exercise results in transient systemic elevations of cytokines. The most significant elevation is seen in interleukin-6 (il-6). Elevated values of il-6 have been reported to enhance fatigue and diminish performance during endurance exercise. A delayed increase in C-reactive protein (CRP) has also been shown in response to il-6. Persistent elevations in systemic interleukin-6 and C-reactive protein values have been associated with increased risk of cardiovascular disease. The purpose of this investigation was to determine whether differences exist in resting and post-exercise measures of il-6 and CRP between trained male endurance athletes and age matched untrained males. Twenty-five eligible males were recruited; thirteen trained (T) mean (SD): age = 26.6(4.9) yrs, mass = 73.0(7.8) kg, height 179.0(5.7) cm, BMI = 22.6(1.4) V02 = 68.6(5.6) m1kg-¹ and twelve untrained (U): age = 23.4(3.8) yrs, mass 77.9(15.0) kg, height = 179.0(8.7) cm, BMI = 23.9(3.0) V02 = 42.4(4.6) m1kg-¹. The two groups were matched for age and body mass index (BMI) and differed significantly in aerobic fitness and hours of exercise per week. Days after an initial aerobic fitness assessment subjects were challenged with a 45 minute cycle ergometer exercise bout at an intensity corresponding to individual ventilatory threshold (VT). Serum il-6 was measured pre-exercise, 30 minutes post-, and 24 hours post-exercise. Serum CRP was measured pre-exercise and 24 hours post-exercise. 11-6 values were analyzed using a 2x3 mixed design ANOVA and CRP using a 2x2 mixed design ANOVA. 11-6 values increased significantly in both groups 30 minutes post-exercise [T Q<0.05) and U (p<O.OS)] and returned to baseline at 24 hours. 11-6 was not different between groups at any time point. CRP values did not increase significantly in either group between pre- and 24 hours post-exercise. CRP values were significantly higher in the untrained group pre- (p<O.OS) and 24 hours post-exercise (p<0.05) compared to the trained group. These results demonstrate no significant difference in il-6 between T and U at rest and or after exercise. This study also demonstrates a reduction in resting and post exercise CRP in endurance trained males compared to untrained males matched for age and BMI.

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