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A synthetic approach to quinocarcin and cyanocycline A : the Ugi reaction of complex aminoacids Turner, Charles Dylan

Abstract

This dissertation describes synthetic efforts towards the natural products quinocarcin and cyanocycline A. Our approach capitalizes on the Ugi reaction of a complex pyroglutamol-derived aminoacid. This ambitious strategy first required the synthesis of the aminoacid, which required considerable development; ultimately the route was optimized to become practical and consistently high-yielding. Ugi condensation reactions using this material were successful, providing advanced precursors of the target molecules.

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Attribution-NonCommercial-NoDerivatives 4.0 International