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UBC Theses and Dissertations

A synthetic approach to quinocarcin and cyanocycline A : the Ugi reaction of complex aminoacids Turner, Charles Dylan


This dissertation describes synthetic efforts towards the natural products quinocarcin and cyanocycline A. Our approach capitalizes on the Ugi reaction of a complex pyroglutamol-derived aminoacid. This ambitious strategy first required the synthesis of the aminoacid, which required considerable development; ultimately the route was optimized to become practical and consistently high-yielding. Ugi condensation reactions using this material were successful, providing advanced precursors of the target molecules.

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