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Mechanisms of Antifungal Properties of Metal Nanoparticles Slavin, Yael N.; Bach, Horacio

Abstract

The appearance of resistant species of fungi to the existent antimycotics is challenging for the scientific community. One emergent technology is the application of nanotechnology to develop novel antifungal agents. Metal nanoparticles (NPs) have shown promising results as an alternative to classical antimycotics. This review summarizes and discusses the antifungal mechanisms of metal NPs, including combinations with other antimycotics, covering the period from 2005 to 2022. These mechanisms include but are not limited to the generation of toxic oxygen species and their cellular target, the effect of the cell wall damage and the hyphae and spores, and the mechanisms of defense implied by the fungal cell. Lastly, a description of the impact of NPs on the transcriptomic and proteomic profiles is discussed.

Item Metadata

Title
Mechanisms of Antifungal Properties of Metal Nanoparticles
Creator
Slavin, Yael N.; Bach, Horacio
Publisher
Multidisciplinary Digital Publishing Institute
Date Issued
2022-12-16
Description
The appearance of resistant species of fungi to the existent antimycotics is challenging for the scientific community. One emergent technology is the application of nanotechnology to develop novel antifungal agents. Metal nanoparticles (NPs) have shown promising results as an alternative to classical antimycotics. This review summarizes and discusses the antifungal mechanisms of metal NPs, including combinations with other antimycotics, covering the period from 2005 to 2022. These mechanisms include but are not limited to the generation of toxic oxygen species and their cellular target, the effect of the cell wall damage and the hyphae and spores, and the mechanisms of defense implied by the fungal cell. Lastly, a description of the impact of NPs on the transcriptomic and proteomic profiles is discussed.
Subject
nanoparticles; metals; ROS; mechanism of defense; fungi; transcriptomics; proteomics; gene regulation; antifungal resistance
Genre
Article
Type
Text
Language
eng
Date Available
2025-06-12
Provider
Vancouver : University of British Columbia Library
Rights
CC BY 4.0
DOI
10.14288/1.0449097
URI
http://hdl.handle.net/2429/91337
Affiliation
Medicine, Faculty of; Non UBC; Medicine, Department of
Citation
Nanomaterials 12 (24): 4470 (2022)
Publisher DOI
10.3390/nano12244470
Peer Review Status
Reviewed
Scholarly Level
Faculty; Researcher
Rights URI
https://creativecommons.org/licenses/by/4.0/
Aggregated Source Repository
DSpace

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CC BY 4.0