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The Blood DNA Methylation Clock GrimAge Is a Robust Surrogate for Airway Epithelia Aging Hernandez Cordero, Ana I.; Yang, Chen Xi; Li, Xuan; Yang, Julia; Shaipanich, Tawimas; MacIsaac, Julie L.; Lin, David T. S.; Kobor, Michael S.; Horvath, Steve; Man, Shu Fan Paul; Sin, Don D.; Leung, Janice M.

Abstract

One key feature of Chronic Obstructive Pulmonary Disease (COPD) is that its prevalence increases exponentially with age. DNA methylation clocks have become powerful biomarkers to detect accelerated aging in a variety of diseases and can help prognose outcomes in severe COPD. This study investigated which DNA methylation clock could best reflect airway epigenetic age when used in more accessible blood samples. Our analyses showed that out of six DNA methylation clocks investigated, DNAmGrimAge demonstrated the strongest correlation and the smallest difference between the airway epithelium and blood. Our findings suggests that blood DNAmGrimAge accurately reflects airway epigenetic age of individuals and that its elevation is highly associated with COPD.

Item Metadata

Title
The Blood DNA Methylation Clock GrimAge Is a Robust Surrogate for Airway Epithelia Aging
Creator
Hernandez Cordero, Ana I.; Yang, Chen Xi; Li, Xuan; Yang, Julia; Shaipanich, Tawimas; MacIsaac, Julie L.; Lin, David T. S.; Kobor, Michael S.; Horvath, Steve; Man, Shu Fan Paul; Sin, Don D.; Leung, Janice M.
Contributor
Centre for Heart Lung Innovation; University of British Columbia. Centre for Molecular Medicine and Therapeutics; St. Paul's Hospital (Vancouver, B.C.)
Publisher
Multidisciplinary Digital Publishing Institute
Date Issued
2022-12-01
Description
One key feature of Chronic Obstructive Pulmonary Disease (COPD) is that its prevalence increases exponentially with age. DNA methylation clocks have become powerful biomarkers to detect accelerated aging in a variety of diseases and can help prognose outcomes in severe COPD. This study investigated which DNA methylation clock could best reflect airway epigenetic age when used in more accessible blood samples. Our analyses showed that out of six DNA methylation clocks investigated, DNAmGrimAge demonstrated the strongest correlation and the smallest difference between the airway epithelium and blood. Our findings suggests that blood DNAmGrimAge accurately reflects airway epigenetic age of individuals and that its elevation is highly associated with COPD.
Subject
COPD; epigenetic age; airway epithelium; blood
Genre
Article
Type
Text
Language
eng
Date Available
2025-06-06
Provider
Vancouver : University of British Columbia Library
Rights
CC BY 4.0
DOI
10.14288/1.0449056
URI
http://hdl.handle.net/2429/91297
Affiliation
Medicine, Faculty of; Non UBC; Medicine, Department of
Citation
Biomedicines 10 (12): 3094 (2022)
Publisher DOI
10.3390/biomedicines10123094
Peer Review Status
Reviewed
Scholarly Level
Faculty; Researcher
Rights URI
https://creativecommons.org/licenses/by/4.0/
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CC BY 4.0