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ICD-10 Codes to Identify Adverse Drug Events Associated with Antibiotics in Administrative Data Lishman, Hannah; Cragg, Amber; Chuang, Erica; Zou, Carl; Marra, Fawziah; Grant, Jennifer M.; Patrick, David, (Physician); Hohl, Corinne M.

Abstract

Antibiotics are among the most used therapeutics in primary care, and while their benefits are clear, the potential harms related to adverse drug events (ADEs) cannot be ignored. We outline the creation of a comprehensive list of diagnostic codes describing antibiotic-associated ADEs resulting in presentations to acute care hospitals. Methods: Previously published ADE codes were used to link BC hospitalizations to prior outpatient antibiotic prescriptions and were restricted based on whether patients received an antibiotic within a month prior to the ADE-related hospitalization. The code list was reviewed by two clinical experts independently for the likelihood of being antibiotic-associated. The inter-rater reliability was calculated using Kappa scores with 95% confidence intervals (CIs). Results: Of the 695 ICD-10 ADE codes with evidence of recent antibiotic administration, 72, 68, and 555 codes were considered likely, possibly, and unlikely antibiotic-associated, respectively. Conclusions: We outline a methodology for developing an ICD-10 code list for antibiotic-associated ADEs severe enough to warrant hospital admission. This will help to improve the use of administrative data to capture antibiotic-associated ADEs.

Item Metadata

Title
ICD-10 Codes to Identify Adverse Drug Events Associated with Antibiotics in Administrative Data
Creator
Lishman, Hannah; Cragg, Amber; Chuang, Erica; Zou, Carl; Marra, Fawziah; Grant, Jennifer M.; Patrick, David, (Physician); Hohl, Corinne M.
Contributor
BC Centre for Disease Control; Vancouver Coastal Health Authority. Research Institute
Publisher
Multidisciplinary Digital Publishing Institute
Date Issued
2025-03-18
Description
Antibiotics are among the most used therapeutics in primary care, and while their benefits are clear, the potential harms related to adverse drug events (ADEs) cannot be ignored. We outline the creation of a comprehensive list of diagnostic codes describing antibiotic-associated ADEs resulting in presentations to acute care hospitals. Methods: Previously published ADE codes were used to link BC hospitalizations to prior outpatient antibiotic prescriptions and were restricted based on whether patients received an antibiotic within a month prior to the ADE-related hospitalization. The code list was reviewed by two clinical experts independently for the likelihood of being antibiotic-associated. The inter-rater reliability was calculated using Kappa scores with 95% confidence intervals (CIs). Results: Of the 695 ICD-10 ADE codes with evidence of recent antibiotic administration, 72, 68, and 555 codes were considered likely, possibly, and unlikely antibiotic-associated, respectively. Conclusions: We outline a methodology for developing an ICD-10 code list for antibiotic-associated ADEs severe enough to warrant hospital admission. This will help to improve the use of administrative data to capture antibiotic-associated ADEs.
Subject
antibiotics; adverse drug events; hospitalization; emergency department; kappa
Genre
Article
Type
Text
Language
eng
Date Available
2025-05-08
Provider
Vancouver : University of British Columbia Library
Rights
CC BY 4.0
DOI
10.14288/1.0448804
URI
http://hdl.handle.net/2429/91043
Affiliation
Medicine, Faculty of; Pharmaceutical Sciences, Faculty of; Emergency Medicine, Department of; Pathology and Laboratory Medicine, Department of; Population and Public Health (SPPH), School of
Citation
Antibiotics 14 (3): 314 (2025)
Publisher DOI
10.3390/antibiotics14030314
Peer Review Status
Reviewed
Scholarly Level
Faculty; Researcher
Rights URI
https://creativecommons.org/licenses/by/4.0/
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CC BY 4.0