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Outcomes of Preterm Infants Admitted to Canadian NICUs Before and During the SARS-COV Pandemic Campbell-Yeo, Marsha; Mireault, Amy; Bacchini, Fabiana; Beltempo, Marc; Shah, Prakesh S.; Alcock, Lynsey; Comeau, Jeannette; Dol, Justine; Grant, Amy; Gubbay, Jonathan; Hughes, Brianna; Hundert, Amos; Inglis, Darlene; Lalani, Yasmin; MacNeil, Morgan; Luu, Thuy Mai; Mitra, Souvik; Narvey, Michael; O’Brien, Karel; Robeson, Paula; Science, Michelle; Canadian Neonatal Network (CNN) Investigators
Abstract
Background: To better elucidate the impact of the SARS-COV pandemic on neonatal outcomes, we compared the health outcomes of infants born preterm requiring care in a Canadian NICU before and during the SARS-COV pandemic. Methods: Using a retrospective cohort study, infants born between 23 and 32 weeks gestation who were admitted to tertiary Canadian NICUs before and during the pandemic were included. A total of 7280 infants were in the pre-pandemic cohort (admitted 1 April 2018–31 December 2019), and 7088 infants were in the pandemic cohort (admitted 1 April 2020–31 December 2021). The primary outcomes included major morbidity or mortality rates. Care strategies and treatments were compared across the two periods. The relative risk (RR) for the pandemic period, compared to the pre-pandemic period, was calculated using a Poisson regression model, adjusted for identified risk factors. Results: There were no significant differences in infant characteristics between the pre-pandemic and pandemic cohorts. The risk of mortality or major morbidity was comparable before and during the pandemic (37% pre-pandemic, 36% pandemic; RR = 1.01, 95% CI 0.92, 1.01). Individual risks for morbidity and mortality did not differ significantly between periods. There was a clinically significant decline in the receipt of the mothers’ own milk exclusively at discharge during the pandemic (45% before and 37% during; RR 0.85, 95% CI 0.68, 1.06). Conclusions: There were no significant differences in major morbidity or mortality rates in preterm infants between pre-pandemic and pandemic cohorts in Canadian NICUs.
Item Metadata
Title |
Outcomes of Preterm Infants Admitted to Canadian NICUs Before and During the SARS-COV Pandemic
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Creator |
Campbell-Yeo, Marsha; Mireault, Amy; Bacchini, Fabiana; Beltempo, Marc; Shah, Prakesh S.; Alcock, Lynsey; Comeau, Jeannette; Dol, Justine; Grant, Amy; Gubbay, Jonathan; Hughes, Brianna; Hundert, Amos; Inglis, Darlene; Lalani, Yasmin; MacNeil, Morgan; Luu, Thuy Mai; Mitra, Souvik; Narvey, Michael; O’Brien, Karel; Robeson, Paula; Science, Michelle; Canadian Neonatal Network (CNN) Investigators
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Contributor | |
Publisher |
Multidisciplinary Digital Publishing Institute
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Date Issued |
2025-02-06
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Description |
Background: To better elucidate the impact of the SARS-COV pandemic on
neonatal outcomes, we compared the health outcomes of infants born preterm requiring
care in a Canadian NICU before and during the SARS-COV pandemic. Methods: Using
a retrospective cohort study, infants born between 23 and 32 weeks gestation who were
admitted to tertiary Canadian NICUs before and during the pandemic were included. A
total of 7280 infants were in the pre-pandemic cohort (admitted 1 April 2018–31 December
2019), and 7088 infants were in the pandemic cohort (admitted 1 April 2020–31 December
2021). The primary outcomes included major morbidity or mortality rates. Care strategies
and treatments were compared across the two periods. The relative risk (RR) for the
pandemic period, compared to the pre-pandemic period, was calculated using a Poisson
regression model, adjusted for identified risk factors. Results: There were no significant
differences in infant characteristics between the pre-pandemic and pandemic cohorts. The
risk of mortality or major morbidity was comparable before and during the pandemic
(37% pre-pandemic, 36% pandemic; RR = 1.01, 95% CI 0.92, 1.01). Individual risks for
morbidity and mortality did not differ significantly between periods. There was a clinically
significant decline in the receipt of the mothers’ own milk exclusively at discharge during
the pandemic (45% before and 37% during; RR 0.85, 95% CI 0.68, 1.06). Conclusions: There
were no significant differences in major morbidity or mortality rates in preterm infants
between pre-pandemic and pandemic cohorts in Canadian NICUs.
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Subject | |
Genre | |
Type | |
Language |
eng
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Date Available |
2025-02-27
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Provider |
Vancouver : University of British Columbia Library
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Rights |
CC BY 4.0
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DOI |
10.14288/1.0448143
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URI | |
Affiliation | |
Citation |
Children 12 (2): 193 (2025)
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Publisher DOI |
10.3390/children12020193
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Peer Review Status |
Reviewed
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Scholarly Level |
Faculty; Researcher
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Rights URI | |
Aggregated Source Repository |
DSpace
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Item Media
Item Citations and Data
Rights
CC BY 4.0