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Nguyen, Quynh; Tung, Lin Wei; Lin, Bruce; Sivakumar, Raam; Sar, Funda; Singhera, Gurpreet; Wang, Ying; Parker, Jeremy; Le Bihan, Stephane; Singh, Amrit; M.V. Rossi, Fabio; Collins, Colin; Bashir, Jamil; Laksman, Zachary

Multidisciplinary Digital Publishing Institute

Spatial transcriptomics has transformed our understanding of gene expression by preserving the spatial context within tissues. This review focuses on the application of spatial transcriptomics in human cardiac tissues, exploring current technologies with a focus on commercially available platforms. We also highlight key studies utilizing spatial transcriptomics to investigate cardiac development, electro-anatomy, immunology, and ischemic heart disease. These studies demonstrate how spatial transcriptomics can be used in conjunction with other omics technologies to provide a more comprehensive picture of human health and disease. Despite its transformative potential, spatial transcriptomics comes with several challenges that limit its widespread adoption and broader application. By addressing these limitations and fostering interdisciplinary collaboration, spatial transcriptomics has the potential to become an essential tool in cardiovascular research. We hope this review serves as a practical guide for researchers interested in adopting spatial transcriptomics, particularly those with limited prior experience, by providing insights into current technologies, applications, and considerations for successful implementation.

Article

eng

Vancouver : University of British Columbia Library

10.14288/1.0448094

Applied Science, Faculty of; Medicine, Faculty of; Other UBC; Anesthesiology, Pharmacology and Therapeutics, Department of; Medical Genetics, Department of; Medicine, Department of; Pathology and Laboratory Medicine, Department of; Surgery, Department of; Urologic Sciences, Department of

10.3390/ijms26030995

Faculty; Researcher

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