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Ji, Haifeng; Yu, Kai; Abbina, Srinivas; Xu, Lin; Xu, Tao; Cheng, Shengjun; Vappala, Sreeparna; Arefi, S.M. Amin; Rana, Md Mohosin; Chafeeva, Irina; Drayton, Matthew; Gonzalez, Kevin; Liu, Yun; Grecov, Dana; Conway, Edward M.; Zhao, Weifeng; Zhao, Changsheng; Kizhakkedathu, Jayachandran N.

Antithrombotic surfaces that prevent coagulation activation without interfering with haemostasis are required for blood-contacting devices. Such materials would restrain device-induced thrombogenesis and decrease the need for anticoagulant use, thereby reducing unwanted bleeding. Here, by optimizing the interactions with coagulation factor XII rather than preventing its surface adsorption, we develop a substrate-independent antithrombotic polymeric coating with sheltered positive charges. The antithrombic properties of the coating were demonstrated in vitro with human blood and in vivo using a carotid artery–jugular vein shunt model in rabbits. The coating exhibits a strong interaction with factor XII but results in a low reciprocal activation of the contact pathway that triggers clot formation. These findings contradict the prevailing strategy of designing antithrombotic materials through protein-repelling surfaces. Overall, the polymeric coating we describe can benefit most blood-contacting devices and is a useful engineering guideline for designing surfaces with improved antithrombotic properties.

Text

2024-11-20

Attribution-NonCommercial-NoDerivatives 4.0 International

http://hdl.handle.net/2429/89686

Ji, H., Yu, K., Abbina, S. et al. Antithrombotic coating with sheltered positive charges prevents contact activation by controlling factor XII–biointerface binding. Nature Materials (2024).

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http://creativecommons.org/licenses/by-nc-nd/4.0/