UBC Faculty Research and Publications

Effect of Exercise on Mental Health and Health-related Quality of Life in Adults With Spinal Cord Injury : A Systematic Review and Meta-Analysis Ponzano, Matteo; Buren, Robert; Adams, Nathan T.; Jun, Jane; Jetha, Arif; Mack, Diane E.; Martin Ginis, Kathleen A. (Kathleen Anne), 1968-

Abstract

Objectives: To determine the effect of exercise interventions on mental health and health-related quality of life (HRQoL) in individuals with SCI. Data Sources: We searched Embase, CINAHL, Medline, PsychINFO, and SPORTDiscus from inception to September 2023. Study Selection: We included randomized controlled trials that (1) involved participants ≥18 years old with a SCI; (2) administered an exercise intervention; and (3) measured subjective well-being, psychological well-being, social well-being, and/or HRQoL as outcomes. We reported standardized means differences (d) with a 95% confidence interval (CI), assessed the risk of bias by using the Revised Cochrane Risk-of-bias Tool for Randomized Trials (RoB 2), and the certainty of the evidence using GRADE. Data Synthesis: Nineteen studies (797 participants, mean age <65 years in every study) were included. Exercise improved overall well-being (d=0.494; 95% CI 0.268, 0.720; low certainty evidence), subjective well-being (d=0.543; 95% CI 0.270, 0.816; low certainty evidence), psychological well-being (d=0.499; 95% CI 0.193, 0.805; low certainty evidence), social well-being (d=0.452; 95% CI 0.151, 0.752; low certainty evidence), and HRQoL (d=0.323; 95% CI 0.072, 0.574; low certainty evidence). Four serious adverse events probably attributable to the interventions were reported in 3 studies. Conclusions: Exercise interventions can improve well-being and HRQoL in adults with SCI <65 years of age. Additional research is needed to determine effectiveness in adults ≥65 years of age.

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