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Gene Therapy for Inherited Arrhythmia Syndromes Leong, Cameron J.; Sharma, Sohat; Seth, Jayant; Dave, Archan; Abdul Ghafoor, Abdul Aziz; Laksman, Zachary

Abstract

The emergence of gene therapy offers opportunities for treating a myriad of genetic disorders and complex diseases that previously had limited or no treatment options. The key basic strategies for gene therapy involve either the addition, inhibition, or introduction of a new gene, with a crucial component being the use of a delivery vector to effectively target cells. Particularly promising is the application of gene therapy for the treatment of inherited arrhythmia syndromes, conditions associated with significant mortality and morbidity that have limited treatment options, and a paucity of disease modifying therapy. This review aims to summarize the utility of gene therapy for the treatment of inherited arrhythmia syndromes by exploring the current state of knowledge, limitations, and future directions.

Item Metadata

Title
Gene Therapy for Inherited Arrhythmia Syndromes
Creator
Leong, Cameron J.; Sharma, Sohat; Seth, Jayant; Dave, Archan; Abdul Ghafoor, Abdul Aziz; Laksman, Zachary
Contributor
Centre for Heart Lung Innovation
Publisher
Multidisciplinary Digital Publishing Institute
Date Issued
2024-08-02
Description
The emergence of gene therapy offers opportunities for treating a myriad of genetic disorders and complex diseases that previously had limited or no treatment options. The key basic strategies for gene therapy involve either the addition, inhibition, or introduction of a new gene, with a crucial component being the use of a delivery vector to effectively target cells. Particularly promising is the application of gene therapy for the treatment of inherited arrhythmia syndromes, conditions associated with significant mortality and morbidity that have limited treatment options, and a paucity of disease modifying therapy. This review aims to summarize the utility of gene therapy for the treatment of inherited arrhythmia syndromes by exploring the current state of knowledge, limitations, and future directions.
Subject
gene therapy; inherited arrhythmia syndromes; cardiogenetics
Genre
Article
Type
Text
Language
eng
Date Available
2024-10-01
Provider
Vancouver : University of British Columbia Library
Rights
CC BY 4.0
DOI
10.14288/1.0445473
URI
http://hdl.handle.net/2429/89318
Affiliation
Applied Science, Faculty of; Medicine, Faculty of; Biomedical Engineering, School of; Medicine, Department of
Citation
Cardiogenetics 14 (3): 132-148 (2024)
Publisher DOI
10.3390/cardiogenetics14030011
Peer Review Status
Reviewed
Scholarly Level
Faculty; Researcher
Rights URI
https://creativecommons.org/licenses/by/4.0/
Aggregated Source Repository
DSpace

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CC BY 4.0