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Nutraceuticals for Diabetic Retinopathy: Recent Advances and Novel Delivery Systems Ye, Xiaoyuan; Fung, Nicholas Siu Kay; Lam, Wai Ching; Lo, Amy Cheuk Yin

Abstract

Diabetic retinopathy (DR) is a major vision-threatening disease among the working-age population worldwide. Present therapeutic strategies such as intravitreal injection of anti-VEGF and laser photocoagulation mainly target proliferative DR. However, there is a need for early effective management in patients with early stage of DR before its progression into the more severe sight-threatening proliferative stage. Nutraceuticals, natural functional foods with few side effects, have been proposed to be beneficial in patients with DR. Over the decades, many studies, either in vitro or in vivo, have demonstrated the advantages of a number of nutraceuticals in DR with their antioxidative, anti-inflammatory, neuroprotective, or vasoprotective effects. However, only a few clinical trials have been conducted, and their outcomes varied. The low bioavailability and instability of many nutraceuticals have indeed hindered their utilization in clinical use. In this context, nanoparticle carriers have been developed to deliver nutraceuticals and to improve their bioavailability. Despite its preclinical nature, research of interventive nutraceuticals for DR may yield promising information in their clinical applications.

Item Metadata

Title
Nutraceuticals for Diabetic Retinopathy: Recent Advances and Novel Delivery Systems
Creator
Ye, Xiaoyuan; Fung, Nicholas Siu Kay; Lam, Wai Ching; Lo, Amy Cheuk Yin
Publisher
Multidisciplinary Digital Publishing Institute
Date Issued
2024-05-30
Description
Diabetic retinopathy (DR) is a major vision-threatening disease among the working-age population worldwide. Present therapeutic strategies such as intravitreal injection of anti-VEGF and laser photocoagulation mainly target proliferative DR. However, there is a need for early effective management in patients with early stage of DR before its progression into the more severe sight-threatening proliferative stage. Nutraceuticals, natural functional foods with few side effects, have been proposed to be beneficial in patients with DR. Over the decades, many studies, either in vitro or in vivo, have demonstrated the advantages of a number of nutraceuticals in DR with their antioxidative, anti-inflammatory, neuroprotective, or vasoprotective effects. However, only a few clinical trials have been conducted, and their outcomes varied. The low bioavailability and instability of many nutraceuticals have indeed hindered their utilization in clinical use. In this context, nanoparticle carriers have been developed to deliver nutraceuticals and to improve their bioavailability. Despite its preclinical nature, research of interventive nutraceuticals for DR may yield promising information in their clinical applications.
Subject
blindness; diabetes; dietary supplement; inflammation; nanotechnology; natural product; neovascularization; oxidative stress; retina; vessel
Genre
Article
Type
Text
Language
eng
Date Available
2024-06-18
Provider
Vancouver : University of British Columbia Library
Rights
CC BY 4.0
DOI
10.14288/1.0443990
URI
http://hdl.handle.net/2429/88486
Affiliation
Medicine, Faculty of; Non UBC; Ophthalmology and Visual Sciences, Department of
Citation
Nutrients 16 (11): 1715 (2024)
Publisher DOI
10.3390/nu16111715
Peer Review Status
Reviewed
Scholarly Level
Faculty
Rights URI
https://creativecommons.org/licenses/by/4.0/
Aggregated Source Repository
DSpace

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CC BY 4.0