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Sex-Based Mechanisms of Cardiac Development and Function: Applications for Induced-Pluripotent Stem Cell Derived-Cardiomyocytes Luo, Yinhan; Safabakhsh, Sina; Palumbo, Alessia; Fiset, Céline; Shen, Carol; Parker, Jeremy; Foster, Leonard J.; Laksman, Zachary

Abstract

Males and females exhibit intrinsic differences in the structure and function of the heart, while the prevalence and severity of cardiovascular disease vary in the two sexes. However, the mechanisms of this sex-based dimorphism are yet to be elucidated. Sex chromosomes and sex hormones are the main contributors to sex-based differences in cardiac physiology and pathophysiology. In recent years, the advances in induced pluripotent stem cell-derived cardiac models and multi-omic approaches have enabled a more comprehensive understanding of the sex-specific differences in the human heart. Here, we provide an overview of the roles of these two factors throughout cardiac development and explore the sex hormone signaling pathways involved. We will also discuss how the employment of stem cell-based cardiac models and single-cell RNA sequencing help us further investigate sex differences in healthy and diseased hearts.

Item Metadata

Title
Sex-Based Mechanisms of Cardiac Development and Function: Applications for Induced-Pluripotent Stem Cell Derived-Cardiomyocytes
Creator
Luo, Yinhan; Safabakhsh, Sina; Palumbo, Alessia; Fiset, Céline; Shen, Carol; Parker, Jeremy; Foster, Leonard J.; Laksman, Zachary
Contributor
Centre for Heart Lung Innovation; UBC Division of Cardiology & Cardiovascular Surgery; University of British Columbia. Centre for Cardiovascular Innovation; Michael Smith Laboratories; University of British Columbia. Integrated Sciences
Publisher
Multidisciplinary Digital Publishing Institute
Date Issued
2024-05-29
Description
Males and females exhibit intrinsic differences in the structure and function of the heart, while the prevalence and severity of cardiovascular disease vary in the two sexes. However, the mechanisms of this sex-based dimorphism are yet to be elucidated. Sex chromosomes and sex hormones are the main contributors to sex-based differences in cardiac physiology and pathophysiology. In recent years, the advances in induced pluripotent stem cell-derived cardiac models and multi-omic approaches have enabled a more comprehensive understanding of the sex-specific differences in the human heart. Here, we provide an overview of the roles of these two factors throughout cardiac development and explore the sex hormone signaling pathways involved. We will also discuss how the employment of stem cell-based cardiac models and single-cell RNA sequencing help us further investigate sex differences in healthy and diseased hearts.
Subject
human-induced pluripotent stem cell; cardiomyocyte; sex hormone; sex hormone receptor; cardiac development; cardiology
Genre
Article
Type
Text
Language
eng
Date Available
2024-06-18
Provider
Vancouver : University of British Columbia Library
Rights
CC BY 4.0
DOI
10.14288/1.0443988
URI
http://hdl.handle.net/2429/88484
Affiliation
Medicine, Faculty of; Non UBC; Biochemistry and Molecular Biology, Department of; Medicine, Department of
Citation
International Journal of Molecular Sciences 25 (11): 5964 (2024)
Publisher DOI
10.3390/ijms25115964
Peer Review Status
Reviewed
Scholarly Level
Faculty; Researcher
Rights URI
https://creativecommons.org/licenses/by/4.0/
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CC BY 4.0