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Human parechovirus infection in young infants : strategies to improve detection and management Kadambari, Seilesh; Harvala, Heli; Simmonds, Peter; Pollard, Andrew J.; Sadarangani, Manish

Abstract

Human parechovirus (HPeV) infections are the second most common cause of viral meningitis in children. HPeV’s are most frequently seen in infants less than 90 days of age. Clinical manifestations include encephalitis, meningitis, myocarditis and sepsis syndrome, which can lead to significant neurodevelopmental sequelae in young infants. Molecular techniques, including polymerase chain reaction assays are the diagnostic tool of choice and have contributed to a marked increase in reported cases, along with an increasing awareness of the aetiological role of HPeV in infant disease. However, focused clinical and diagnostic investigations for HPeV in infants and the use of such information in management is variable due in part to the lack of robust incidence data and its range of clinical presentations. In this review, we outline recent clinical cohort and epidemiological studies which can be used to inform the evidence based management of young infants with HPeV disease and also identify key research priorities. A better understanding of the pathogenesis and epidemiology of HPeV infections is required to inform an evidence-based approach to diagnosis and treatment in the future.

Item Metadata

Title
Human parechovirus infection in young infants : strategies to improve detection and management
Creator
Kadambari, Seilesh; Harvala, Heli; Simmonds, Peter; Pollard, Andrew J.; Sadarangani, Manish
Contributor
Children's Hospital (Vancouver, B.C.). Vaccine Evaluation Center; Children's Hospital (Vancouver, B.C.). Research Institute
Publisher
Elsevier
Date Issued
2019-02
Description
Human parechovirus (HPeV) infections are the second most common cause of viral meningitis in children. HPeV’s are most frequently seen in infants less than 90 days of age. Clinical manifestations include encephalitis, meningitis, myocarditis and sepsis syndrome, which can lead to significant neurodevelopmental sequelae in young infants. Molecular techniques, including polymerase chain reaction assays are the diagnostic tool of choice and have contributed to a marked increase in reported cases, along with an increasing awareness of the aetiological role of HPeV in infant disease. However, focused clinical and diagnostic investigations for HPeV in infants and the use of such information in management is variable due in part to the lack of robust incidence data and its range of clinical presentations. In this review, we outline recent clinical cohort and epidemiological studies which can be used to inform the evidence based management of young infants with HPeV disease and also identify key research priorities. A better understanding of the pathogenesis and epidemiology of HPeV infections is required to inform an evidence-based approach to diagnosis and treatment in the future.
Subject
Parechovirus; Encephalitis; Meningitis; Sepsis; Infants; Diagnosis; Treatment
Genre
Article; Postprint
Type
Text
Language
eng
Date Available
2024-03-27
Provider
Vancouver : University of British Columbia Library
Rights
Attribution-NonCommercial-NoDerivatives 4.0 International
DOI
10.14288/1.0440949
URI
http://hdl.handle.net/2429/87641
Affiliation
Medicine, Faculty of; Non UBC; Pediatrics, Department of
Citation
Seilesh Kadambari, Heli Harvala, Peter Simmonds, Andrew J Pollard, Manish Sadarangani . Strategies to improve detection and management of human parechovirus infection in young infants. The Lancet infectious Disease 2019; 19: e51-e58.
Publisher DOI
10.1016/S1473-3099(18)30288-3
Peer Review Status
Reviewed
Scholarly Level
Faculty; Researcher
Rights URI
http://creativecommons.org/licenses/by-nc-nd/4.0/
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Attribution-NonCommercial-NoDerivatives 4.0 International