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The PPD-ACT app in Canada : feasibility and a latent class analysis of participants with postpartum depression recruited to a psychiatric genetics study using a mobile application Collaton, Joanna; Dennis, Cindy-Lee; Taylor, Valerie H.; Grigoriadis, Sophie; Oberlander, Tim F.; Frey, Benicio N.; Van Lieshout, Ryan; Guintivano, Jerry; Meltzer-Brody, Samantha; Kennedy, James L.; Vigod, Simone N.
Abstract
Background: Postpartum depression (PPD) and postpartum psychosis (PPP) are linked to negative consequences for women and families. Virtual applications present a solution to the challenge of recruiting large samples for genetic PPD/PPP research. This study aimed to evaluate the feasibility of a protocol for enrolling Canadian women with PPD and PPP to a large international psychiatric genetics study using a mobile application (PPD-ACT), and identify clinically distinct subtypes of PPD in the recruited sample. Methods: From April 2017–June 2019, Canadian women provided phenotypic data through the PPD-ACT app. Requests for a genetic sample were made from those with a current or past PPD episode based on an Edinburgh Postnatal Depression Scale (EPDS) score > 12 with onset in pregnancy or 0–3 months postpartum, and from those self-reporting lifetime PPP. Latent class analysis (LCA) was used to identify clinically distinct PPD subgroups based on participant responses to the EPDS scale. Results: We identified 797 PPD cases, 404 of whom submitted DNA. There were 109 PPP cases, with 66 submitting DNA. PPD cases (86.7% White, mean 4.7 +/− 7.0 years since their episode) came from across Canadian provinces/territories. LCA identified two PPD classes clinically distinct by symptom severity: [1] moderate-severity (mean EPDS = 18.5+/− 2.5; 8.6% with suicidality), and [2] severe (mean EPDS = 24.5+/− 2.1; 52.8% with suicidality). Conclusions: A mobile application rapidly collected data from individuals with moderate and severe symptoms of PPD, an advantage for genetics where specificity is optimal, as well as from women with a history of PPP, supporting future work using this approach.
Item Metadata
| Title |
The PPD-ACT app in Canada : feasibility and a latent class analysis of participants with postpartum depression recruited to a psychiatric genetics study using a mobile application
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| Creator | |
| Contributor | |
| Publisher |
BioMed Central
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| Date Issued |
2022-11-24
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| Description |
Background:
Postpartum depression (PPD) and postpartum psychosis (PPP) are linked to negative consequences for women and families. Virtual applications present a solution to the challenge of recruiting large samples for genetic PPD/PPP research. This study aimed to evaluate the feasibility of a protocol for enrolling Canadian women with PPD and PPP to a large international psychiatric genetics study using a mobile application (PPD-ACT), and identify clinically distinct subtypes of PPD in the recruited sample.
Methods:
From April 2017–June 2019, Canadian women provided phenotypic data through the PPD-ACT app. Requests for a genetic sample were made from those with a current or past PPD episode based on an Edinburgh Postnatal Depression Scale (EPDS) score > 12 with onset in pregnancy or 0–3 months postpartum, and from those self-reporting lifetime PPP. Latent class analysis (LCA) was used to identify clinically distinct PPD subgroups based on participant responses to the EPDS scale.
Results:
We identified 797 PPD cases, 404 of whom submitted DNA. There were 109 PPP cases, with 66 submitting DNA. PPD cases (86.7% White, mean 4.7 +/− 7.0 years since their episode) came from across Canadian provinces/territories. LCA identified two PPD classes clinically distinct by symptom severity: [1] moderate-severity (mean EPDS = 18.5+/− 2.5; 8.6% with suicidality), and [2] severe (mean EPDS = 24.5+/− 2.1; 52.8% with suicidality).
Conclusions:
A mobile application rapidly collected data from individuals with moderate and severe symptoms of PPD, an advantage for genetics where specificity is optimal, as well as from women with a history of PPP, supporting future work using this approach.
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| Subject | |
| Genre | |
| Type | |
| Language |
eng
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| Date Available |
2023-12-04
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| Provider |
Vancouver : University of British Columbia Library
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| Rights |
Attribution 4.0 International (CC BY 4.0)
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| DOI |
10.14288/1.0438010
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| URI | |
| Affiliation | |
| Citation |
BMC Psychiatry. 2022 Nov 24;22(1):735
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| Publisher DOI |
10.1186/s12888-022-04363-7
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| Peer Review Status |
Reviewed
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| Scholarly Level |
Faculty; Researcher
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| Copyright Holder |
The Author(s)
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| Rights URI | |
| Aggregated Source Repository |
DSpace
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Rights
Attribution 4.0 International (CC BY 4.0)