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Hematopoietic Cell Transplantation for Systemic Sclerosis : A Review Levin, Daniel; Osman, Mohammed S.; Durand, Caylib; Kim, Hyein; Hemmati, Iman; Jamani, Kareem; Howlett, Jonathan G.; Johannson, Kerri A.; Weatherald, Jason; Woo, Matthew; Lee, Jason; Storek, Jan

Abstract

Systemic sclerosis (SSc) is an autoimmune, multi-organ, connective tissue disease associated with significant morbidity and mortality. Conventional immunosuppressive therapies demonstrate limited efficacy. Autologous hematopoietic stem cell transplantation (HCT) is more efficacious but carries associated risks, including treatment-related mortality. Here, we review HCT as a treatment for SSc, its efficacy and toxicity in comparison to conventional therapies, and the proposed mechanisms of action. Furthermore, we discuss the importance of and recent developments in patient selection. Finally, we highlight the knowledge gaps and future work required to further improve patient outcomes.

Item Metadata

Title
Hematopoietic Cell Transplantation for Systemic Sclerosis : A Review
Creator
Levin, Daniel; Osman, Mohammed S.; Durand, Caylib; Kim, Hyein; Hemmati, Iman; Jamani, Kareem; Howlett, Jonathan G.; Johannson, Kerri A.; Weatherald, Jason; Woo, Matthew; Lee, Jason; Storek, Jan
Publisher
Multidisciplinary Digital Publishing Institute
Date Issued
2022-12-03
Description
Systemic sclerosis (SSc) is an autoimmune, multi-organ, connective tissue disease associated with significant morbidity and mortality. Conventional immunosuppressive therapies demonstrate limited efficacy. Autologous hematopoietic stem cell transplantation (HCT) is more efficacious but carries associated risks, including treatment-related mortality. Here, we review HCT as a treatment for SSc, its efficacy and toxicity in comparison to conventional therapies, and the proposed mechanisms of action. Furthermore, we discuss the importance of and recent developments in patient selection. Finally, we highlight the knowledge gaps and future work required to further improve patient outcomes.
Subject
systemic sclerosis; hematopoietic stem cell transplant; sclerosis; ILD
Genre
Article
Type
Text
Language
eng
Date Available
2023-11-20
Provider
Vancouver : University of British Columbia Library
Rights
CC BY 4.0
DOI
10.14288/1.0437785
URI
http://hdl.handle.net/2429/86631
Affiliation
Medicine, Faculty of; Non UBC
Citation
Cells 11 (23): 3912 (2022)
Publisher DOI
10.3390/cells11233912
Peer Review Status
Reviewed
Scholarly Level
Faculty; Researcher; Graduate
Rights URI
https://creativecommons.org/licenses/by/4.0/
Aggregated Source Repository
DSpace

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CC BY 4.0