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Pediatric Brain Tumours : Lessons from the Immune Microenvironment Yao, Betty; Delaidelli, Alberto; Vogel, Hannes; Sorensen, Poul H.

Abstract

In spite of recent advances in tumour molecular subtyping, pediatric brain tumours (PBTs) remain the leading cause of cancer-related deaths in children. While some PBTs are treatable with favourable outcomes, recurrent and metastatic disease for certain types of PBTs remains challenging and is often fatal. Tumour immunotherapy has emerged as a hopeful avenue for the treatment of childhood tumours, and recent immunotherapy efforts have been directed towards PBTs. This strategy has the potential to combat otherwise incurable PBTs, while minimizing off-target effects and long-term sequelae. As the infiltration and activation states of immune cells, including tumour-infiltrating lymphocytes and tumour-associated macrophages, are key to shaping responses towards immunotherapy, this review explores the immune landscape of the developing brain and discusses the tumour immune microenvironments of common PBTs, with hopes of conferring insights that may inform future treatment design.

Item Metadata

Title
Pediatric Brain Tumours : Lessons from the Immune Microenvironment
Creator
Yao, Betty; Delaidelli, Alberto; Vogel, Hannes; Sorensen, Poul H.
Contributor
BC Cancer Research Centre. Molecular Oncology
Publisher
Multidisciplinary Digital Publishing Institute
Date Issued
2023-05-15
Description
In spite of recent advances in tumour molecular subtyping, pediatric brain tumours (PBTs) remain the leading cause of cancer-related deaths in children. While some PBTs are treatable with favourable outcomes, recurrent and metastatic disease for certain types of PBTs remains challenging and is often fatal. Tumour immunotherapy has emerged as a hopeful avenue for the treatment of childhood tumours, and recent immunotherapy efforts have been directed towards PBTs. This strategy has the potential to combat otherwise incurable PBTs, while minimizing off-target effects and long-term sequelae. As the infiltration and activation states of immune cells, including tumour-infiltrating lymphocytes and tumour-associated macrophages, are key to shaping responses towards immunotherapy, this review explores the immune landscape of the developing brain and discusses the tumour immune microenvironments of common PBTs, with hopes of conferring insights that may inform future treatment design.
Subject
tumour immune microenvironment; pediatric brain tumour; immunotherapy; medulloblastoma; pediatric high-grade glioma; tumour-infiltrating lymphocytes; tumour-infiltrating macrophages
Genre
Article
Type
Text
Language
eng
Date Available
2023-11-14
Provider
Vancouver : University of British Columbia Library
Rights
CC BY 4.0
DOI
10.14288/1.0437664
URI
http://hdl.handle.net/2429/86502
Affiliation
Medicine, Faculty of; Non UBC; Pathology and Laboratory Medicine, Department of
Citation
Current Oncology 30 (5): 5024-5046 (2023)
Publisher DOI
10.3390/curroncol30050379
Peer Review Status
Reviewed
Scholarly Level
Faculty; Researcher; Postdoctoral
Rights URI
https://creativecommons.org/licenses/by/4.0/
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CC BY 4.0