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Age at Natural Menopause in Women Living with HIV : A Cross-Sectional Study Comparing Self-Reported and Biochemical Data Swann, Shayda A.; King, Elizabeth M.; Tognazzini, Shelly; Campbell, Amber R.; Levy, Sofia L. A.; Pick, Neora; Prior, Jerilynn C., 1943-; Elwood, Chelsea; Loutfy, Mona; Nicholson, Valerie; et al.
Abstract
Early menopause (<45 years) has significant impacts on bone, cardiovascular, and cognitive health. Several studies have suggested earlier menopause for women living with HIV; however, the current literature is limited by reliance on self-report data. We determined age at menopause in women living with HIV and socio-demographically similar HIV-negative women based on both self-report of menopause status (no menses for ≥12 months) and biochemical confirmation (defined as above plus follicle-stimulating hormone level ≥ 25 IU/mL). Multivariable median regression models assessed factors associated with menopause age, controlling for relevant confounders. Overall, 91 women living with HIV and 98 HIV-negative women were categorized as menopausal by selfreport, compared to 83 and 92 by biochemical confirmation. Age at menopause did not differ significantly between groups, whether based on self-report (median [IQR]: 49.0 [45.3 to 53.0] vs. 50.0 [46.0 to 53.0] years; p = 0.28) or biochemical confirmation (50.0 [46.0 to 53.0] vs. 51.0 [46.0 to 53.0] years; p = 0.54). In the multivariable model, no HIV-related or psychosocial variables were associated with earlier age at menopause (all p > 0.05). Overall, HIV status per se was not statistically associated with an earlier age at menopause, emphasizing the importance of comparing socio-demographically similar women in reproductive health and HIV research.
Item Metadata
Title |
Age at Natural Menopause in Women Living with HIV : A Cross-Sectional Study Comparing Self-Reported and Biochemical Data
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Creator | |
Contributor | |
Publisher |
Multidisciplinary Digital Publishing Institute
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Date Issued |
2023-04-26
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Description |
Early menopause (<45 years) has significant impacts on bone, cardiovascular, and cognitive
health. Several studies have suggested earlier menopause for women living with HIV; however,
the current literature is limited by reliance on self-report data. We determined age at menopause
in women living with HIV and socio-demographically similar HIV-negative women based on both
self-report of menopause status (no menses for ≥12 months) and biochemical confirmation (defined
as above plus follicle-stimulating hormone level ≥ 25 IU/mL). Multivariable median regression
models assessed factors associated with menopause age, controlling for relevant confounders. Overall,
91 women living with HIV and 98 HIV-negative women were categorized as menopausal by selfreport, compared to 83 and 92 by biochemical confirmation. Age at menopause did not differ
significantly between groups, whether based on self-report (median [IQR]: 49.0 [45.3 to 53.0] vs. 50.0
[46.0 to 53.0] years; p = 0.28) or biochemical confirmation (50.0 [46.0 to 53.0] vs. 51.0 [46.0 to 53.0]
years; p = 0.54). In the multivariable model, no HIV-related or psychosocial variables were associated
with earlier age at menopause (all p > 0.05). Overall, HIV status per se was not statistically associated
with an earlier age at menopause, emphasizing the importance of comparing socio-demographically
similar women in reproductive health and HIV research.
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Subject | |
Genre | |
Type | |
Language |
eng
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Date Available |
2023-11-15
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Provider |
Vancouver : University of British Columbia Library
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Rights |
CC BY 4.0
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DOI |
10.14288/1.0437648
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URI | |
Affiliation | |
Citation |
Viruses 15 (5): 1058 (2023)
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Publisher DOI |
10.3390/v15051058
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Peer Review Status |
Reviewed
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Scholarly Level |
Faculty; Researcher; Graduate; Undergraduate
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Rights URI | |
Aggregated Source Repository |
DSpace
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Item Media
Item Citations and Data
Rights
CC BY 4.0