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Age at Natural Menopause in Women Living with HIV : A Cross-Sectional Study Comparing Self-Reported and Biochemical Data Swann, Shayda A.; King, Elizabeth M.; Tognazzini, Shelly; Campbell, Amber R.; Levy, Sofia L. A.; Pick, Neora; Prior, Jerilynn C., 1943-; Elwood, Chelsea; Loutfy, Mona; Nicholson, Valerie; Kaida, Angela; Côté, Hélène C. F.; Murray, Melanie C. M.

Abstract

Early menopause (<45 years) has significant impacts on bone, cardiovascular, and cognitive health. Several studies have suggested earlier menopause for women living with HIV; however, the current literature is limited by reliance on self-report data. We determined age at menopause in women living with HIV and socio-demographically similar HIV-negative women based on both self-report of menopause status (no menses for ≥12 months) and biochemical confirmation (defined as above plus follicle-stimulating hormone level ≥ 25 IU/mL). Multivariable median regression models assessed factors associated with menopause age, controlling for relevant confounders. Overall, 91 women living with HIV and 98 HIV-negative women were categorized as menopausal by selfreport, compared to 83 and 92 by biochemical confirmation. Age at menopause did not differ significantly between groups, whether based on self-report (median [IQR]: 49.0 [45.3 to 53.0] vs. 50.0 [46.0 to 53.0] years; p = 0.28) or biochemical confirmation (50.0 [46.0 to 53.0] vs. 51.0 [46.0 to 53.0] years; p = 0.54). In the multivariable model, no HIV-related or psychosocial variables were associated with earlier age at menopause (all p > 0.05). Overall, HIV status per se was not statistically associated with an earlier age at menopause, emphasizing the importance of comparing socio-demographically similar women in reproductive health and HIV research.

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Title
Age at Natural Menopause in Women Living with HIV : A Cross-Sectional Study Comparing Self-Reported and Biochemical Data
Creator
Swann, Shayda A.; King, Elizabeth M.; Tognazzini, Shelly; Campbell, Amber R.; Levy, Sofia L. A.; Pick, Neora; Prior, Jerilynn C., 1943-; Elwood, Chelsea; Loutfy, Mona; Nicholson, Valerie; Kaida, Angela; Côté, Hélène C. F.; Murray, Melanie C. M.
Contributor
Women's Health Research Institute (British Columbia); BC Women’s Hospital and Health Centre; Centre for Menstrual Cycle and Ovulation Research; University of British Columbia. Centre for Blood Research; Edwin S.H. Leong Healthy Aging Program
Publisher
Multidisciplinary Digital Publishing Institute
Date Issued
2023-04-26
Description
Early menopause (<45 years) has significant impacts on bone, cardiovascular, and cognitive health. Several studies have suggested earlier menopause for women living with HIV; however, the current literature is limited by reliance on self-report data. We determined age at menopause in women living with HIV and socio-demographically similar HIV-negative women based on both self-report of menopause status (no menses for ≥12 months) and biochemical confirmation (defined as above plus follicle-stimulating hormone level ≥ 25 IU/mL). Multivariable median regression models assessed factors associated with menopause age, controlling for relevant confounders. Overall, 91 women living with HIV and 98 HIV-negative women were categorized as menopausal by selfreport, compared to 83 and 92 by biochemical confirmation. Age at menopause did not differ significantly between groups, whether based on self-report (median [IQR]: 49.0 [45.3 to 53.0] vs. 50.0 [46.0 to 53.0] years; p = 0.28) or biochemical confirmation (50.0 [46.0 to 53.0] vs. 51.0 [46.0 to 53.0] years; p = 0.54). In the multivariable model, no HIV-related or psychosocial variables were associated with earlier age at menopause (all p > 0.05). Overall, HIV status per se was not statistically associated with an earlier age at menopause, emphasizing the importance of comparing socio-demographically similar women in reproductive health and HIV research.
Subject
menopause age; HIV; women’s health; follicle-stimulating hormone; early menopause
Genre
Article
Type
Text
Language
eng
Date Available
2023-11-15
Provider
Vancouver : University of British Columbia Library
Rights
CC BY 4.0
DOI
10.14288/1.0437648
URI
http://hdl.handle.net/2429/86518
Affiliation
Medicine, Faculty of; Science, Faculty of; Other UBC; Non UBC; Medicine, Department of; Obstetrics and Gynaecology, Department of; Pathology and Laboratory Medicine, Department of; Population and Public Health (SPPH), School of
Citation
Viruses 15 (5): 1058 (2023)
Publisher DOI
10.3390/v15051058
Peer Review Status
Reviewed
Scholarly Level
Faculty; Researcher; Graduate; Undergraduate
Rights URI
https://creativecommons.org/licenses/by/4.0/
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CC BY 4.0