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Epigenetics in Heart Failure: Role of DNA Methylation in Potential Pathways Leading to Heart Failure with Preserved Ejection Fraction Rabkin, Simon; Wong, Chenille N.

Abstract

This review will focus on epigenetic modifications utilizing the DNA methylation mechanism, which is potentially involved in the pathogenesis of heart failure with preserved ejection fraction (HFpEF). The putative pathways of HFpEF will be discussed, specifically myocardial fibrosis, myocardial inflammation, sarcoplasmic reticulum Ca2+-ATPase, oxidative–nitrosative stress, mitochondrial and metabolic defects, as well as obesity. The relationship of HFpEF to aging and atrial fibrillation will be examined from the perspective of DNA methylation.

Item Metadata

Title
Epigenetics in Heart Failure: Role of DNA Methylation in Potential Pathways Leading to Heart Failure with Preserved Ejection Fraction
Creator
Rabkin, Simon; Wong, Chenille N.
Contributor
UBC Division of Cardiology & Cardiovascular Surgery
Publisher
Multidisciplinary Digital Publishing Institute
Date Issued
2023-10-17
Description
This review will focus on epigenetic modifications utilizing the DNA methylation mechanism, which is potentially involved in the pathogenesis of heart failure with preserved ejection fraction (HFpEF). The putative pathways of HFpEF will be discussed, specifically myocardial fibrosis, myocardial inflammation, sarcoplasmic reticulum Ca2+-ATPase, oxidative–nitrosative stress, mitochondrial and metabolic defects, as well as obesity. The relationship of HFpEF to aging and atrial fibrillation will be examined from the perspective of DNA methylation.
Subject
DNA methylation; heart failure with preserved ejection fraction; cardiac fibrosis; obesity; cardiac metabolism
Genre
Article
Type
Text
Language
eng
Date Available
2023-11-10
Provider
Vancouver : University of British Columbia Library
Rights
CC BY 4.0
DOI
10.14288/1.0437591
URI
http://hdl.handle.net/2429/86487
Affiliation
Medicine, Faculty of; Medicine, Department of
Citation
Biomedicines 11 (10): 2815 (2023)
Publisher DOI
10.3390/biomedicines11102815
Peer Review Status
Reviewed
Scholarly Level
Faculty
Rights URI
https://creativecommons.org/licenses/by/4.0/
Aggregated Source Repository
DSpace

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CC BY 4.0