Open Collections

UBC Faculty Research and Publications

Sex differences in Drosophila development and physiology Millington, Jason W.; Rideout, Elizabeth

Abstract

Male and female flies differ in many aspects of development and physiology. Identifying the mechanism(s) underlying sex differences in cell and body growth, organ function, and metabolism is important in understanding how these male-female differences in development and physiology are created. Recently, studies in Drosophila have advanced our understanding of the sex-specific regulation of growth and cell signaling pathways, organ homeostasis, and metabolism. Here, we highlight how this knowledge provides important insight into the mechanisms underlying sex differences in body size, stress responses, lifespan, and disease processes. In addition, we will discuss how studying development and physiology has revealed previously unrecognized complexity in the Drosophila sex determination pathway

Item Metadata

Title
Sex differences in Drosophila development and physiology
Creator
Millington, Jason W.; Rideout, Elizabeth
Contributor
University of British Columbia. Life Sciences Institute
Date Issued
2018
Description
Male and female flies differ in many aspects of development and physiology. Identifying the mechanism(s) underlying sex differences in cell and body growth, organ function, and metabolism is important in understanding how these male-female differences in development and physiology are created. Recently, studies in Drosophila have advanced our understanding of the sex-specific regulation of growth and cell signaling pathways, organ homeostasis, and metabolism. Here, we highlight how this knowledge provides important insight into the mechanisms underlying sex differences in body size, stress responses, lifespan, and disease processes. In addition, we will discuss how studying development and physiology has revealed previously unrecognized complexity in the Drosophila sex determination pathway
Subject
Drosophila; sex differences; physiology; development; metabolism; insulin signaling; intestinal stem cell; body size; sex determination; lifespan
Genre
Article; Postprint
Type
Text
Language
eng
Date Available
2023-11-01
Provider
Vancouver : University of British Columbia Library
Rights
Attribution-NonCommercial-NoDerivatives 4.0 International
DOI
10.14288/1.0437495
URI
http://hdl.handle.net/2429/86417
Affiliation
Medicine, Faculty of; Cellular and Physiological Sciences, Department of
Citation
Millington, J.W. and Rideout, E.J. (2018) Sex differences in Drosophila development and physiology. Curr Opin Physiol. 6, 46-56.
Publisher DOI
10.1016/j.cophys.2018.04.002
Peer Review Status
Reviewed
Scholarly Level
Faculty; Graduate
Rights URI
http://creativecommons.org/licenses/by-nc-nd/4.0/
Aggregated Source Repository
DSpace

Item Media

Item Citations and Data

Rights

Attribution-NonCommercial-NoDerivatives 4.0 International