UBC Faculty Research and Publications

Topical AHA in Dermatology: Formulations, Mechanisms of Action, Efficacy, and Future Perspectives Karwal, Kanwarpreet; Mukovozov, Ilya


The utilization of topical formulations containing alpha hydroxy acids (AHAs) has garnered considerable attention. This review summarizes the effectiveness of the most common topical AHA formulations, including mechanisms of action and future research directions. AHAs have a dramatic impact on diverse skin conditions, enhancing texture and stimulating collagen synthesis. Uncertainties persist regarding optimal concentration, pH, and vehicle for maximum efficacy. Advancements in formulation technologies offer opportunities for AHA penetration and stability. Understanding mechanisms is vital for skincare optimization. The review covers AHAs, their concentrations, formulation considerations, safety measures, and future directions.

Item Media

Item Citations and Data


CC BY 4.0