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From Theory to Practice : Implementing the WHO 2021 Classification of Adult Diffuse Gliomas in Neuropathology Diagnosis Martin, Karina Chornenka; Ma, Crystal; Yip, Stephen

Abstract

Diffuse gliomas are the most common type of primary central nervous system (CNS) neoplasm to affect the adult population. The diagnosis of adult diffuse gliomas is dependent upon the integration of morphological features of the tumour with its underlying molecular alterations, and the integrative diagnosis has become of increased importance in the fifth edition of the WHO classification of CNS neoplasms (WHO CNS5). The three major diagnostic entities of adult diffuse gliomas are as follows: (1) astrocytoma, IDH-mutant; (2) oligodendroglioma, IDH-mutant and 1p/19q-codeleted; and (3) glioblastoma, IDH-wildtype. The aim of this review is to summarize the pathophysiology, pathology, molecular characteristics, and major diagnostic updates encountered in WHO CNS5 of adult diffuse gliomas. Finally, the application of implementing the necessary molecular tests for diagnostic workup of these entities in the pathology laboratory setting is discussed.

Item Metadata

Title
From Theory to Practice : Implementing the WHO 2021 Classification of Adult Diffuse Gliomas in Neuropathology Diagnosis
Creator
Martin, Karina Chornenka; Ma, Crystal; Yip, Stephen
Publisher
Multidisciplinary Digital Publishing Institute
Date Issued
2023-05-18
Description
Diffuse gliomas are the most common type of primary central nervous system (CNS) neoplasm to affect the adult population. The diagnosis of adult diffuse gliomas is dependent upon the integration of morphological features of the tumour with its underlying molecular alterations, and the integrative diagnosis has become of increased importance in the fifth edition of the WHO classification of CNS neoplasms (WHO CNS5). The three major diagnostic entities of adult diffuse gliomas are as follows: (1) astrocytoma, IDH-mutant; (2) oligodendroglioma, IDH-mutant and 1p/19q-codeleted; and (3) glioblastoma, IDH-wildtype. The aim of this review is to summarize the pathophysiology, pathology, molecular characteristics, and major diagnostic updates encountered in WHO CNS5 of adult diffuse gliomas. Finally, the application of implementing the necessary molecular tests for diagnostic workup of these entities in the pathology laboratory setting is discussed.
Subject
diffuse glioma; astrocytoma; IDH-mutant; oligodendroglioma; 1p19q-codeleted; glioblastoma; IDH-wildtype; integrative diagnosis
Genre
Article
Type
Text
Language
eng
Date Available
2023-09-05
Provider
Vancouver : University of British Columbia Library
Rights
CC BY 4.0
DOI
10.14288/1.0435744
URI
http://hdl.handle.net/2429/85806
Affiliation
Medicine, Faculty of; Pathology and Laboratory Medicine, Department of
Citation
Martin, K.C.; Ma, C.; Yip, S. From Theory to Practice: Implementing the WHO 2021 Classification of Adult Diffuse Gliomas in Neuropathology Diagnosis. Brain Sci. 2023, 13, 817.
Publisher DOI
10.3390/brainsci13050817
Peer Review Status
Reviewed
Scholarly Level
Faculty; Graduate; Undergraduate
Rights URI
https://creativecommons.org/licenses/by/4.0/
Aggregated Source Repository
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CC BY 4.0